Wnt/β-catenin signaling in development and cancer

The paper characterizes protein isoforms of the Drosophila sgg gene, revealing distinct localization, interactions, and functions for different proteoforms during development.

This study shows Nanog represses maternal β-catenin activity by interfering with TCF factors, preventing hyper-dorsalization in early embryos.

This paper describes a novel Axin2 knock-in mouse model that visualizes and traces WNT/CTNNB1 responsive cells through fluorescent reporting and lineage tracing.

This study uses single-molecule imaging to analyze Dvl2 dynamics and oligomerization during Wnt pathway activation, showing increased oligomerization and dwell time upon Wnt3a stimulation.

This study shows ADNP is essential for neural differentiation by maintaining Wnt/β-catenin signaling, and its disruption causes neural developmental defects in mice and zebrafish.

This study identifies FZD10 as a receptor for Wnt1 in spinal cord development, showing it regulates neurogenesis and proliferation, but requires Lrp6 for full activity.

This study shows Lgr5 regulates extracellular matrix production in fetal intestinal stem cells, affecting their maturation and niche environment.

The paper investigates the functional redundancy and additivity of four Lef/Tcf transcription factors in lung epithelial progenitors using genetic knockout models in mice.

The paper examines variability in β-catenin pulse dynamics during a stochastic cell fate decision in C. elegans and links BAR-1 pulse timing to cell fate outcome.

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.

The paper develops an agent-based model to study the interaction between Hippo and Wnt signaling pathways in intestinal crypts, showing Hippo reduces β-catenin and slows crypt turnover, and division-based Wnt spreading can form gradients.

The paper identifies tcf7l2 splice variants that mediate repressor functions in eye formation by interacting with Tle co-repressors and phosphorylated residues.

This study identifies ΔN-Tp63 as a key mediator of Wnt/β-catenin signaling in basal stem cells of mucociliary epithelia, showing its role in inhibiting differentiation and promoting hyperplasia.

This study shows that umbelliprenin inhibits gastric cancer cell migration and growth by disrupting the Wnt signaling pathway.

The paper investigates how TGFβ ligands alter WNT/{beta}-catenin signaling dynamics during human pluripotent cell differentiation, showing a shift from transient to sustained responses.

This study shows that Iduna regulates Axin proteolysis, which controls stem cell proliferation and intestinal homeostasis in Drosophila.

This study identifies the role of Wnt/Fgf crosstalk in tracheal basal progenitor cell specification through genetic ablation experiments in mouse models.

This study identifies a direct link between SP1 and β-catenin in the Wnt signaling pathway, showing their mutual stabilization and role in target gene expression.

This paper investigates how Wnt signaling affects the localization, molecular size, and activity of the beta-catenin destruction complex in Drosophila embryos, revealing new insights into complex regulation.

This study shows RSPO2 and RSPO3 can enhance WNT/β-catenin signaling without LGR receptors, while RSPO1 and RSPO4 cannot, revealing two distinct RSPO signaling mechanisms.

The paper investigates how Wnt/beta-catenin signaling in neighboring cells affects transcriptome heterogeneity and proliferative fate in mouse keratinocytes.

The paper combines optogenetics and light-sheet microscopy to study Wnt signaling in Drosophila embryos, showing light-induced inhibition of Wnt signaling and its role in development.

The paper develops an in vivo Drosophila assay to distinguish Wnt pathway transcriptional responses, identifying gene sets regulated by β-catenin, TCF, and non-canonical Wnt4.