Mark A. Peifer

The paper investigates the functional redundancy of stickers and spacers in the intrinsically disordered region of Canoe, revealing their roles in AJ function and robustness.

The paper identifies junctional proteins critical for mesenchymal migration and testis morphogenesis in Drosophila using a combination of proximity proteomics and genome-wide shRNA screening.

The paper identifies conserved stickers in the Canoe IDR that bind F-actin, showing their combinatorial role in junctional localization, mechanosensing, and function during morphogenesis.

The paper shows that a nematic liquid crystal state forms during gastrulation in fish, frogs, and fruit flies through a common mechanism, with experimental and theoretical support.

The paper identifies a contact-dependent mechanism involving Plexin A and Semaphorin 1B that drives gap closure and organ sculpting during collective cell migration in Drosophila.

The paper uses proximity proteomics to identify proteins interacting with Afadin in MDCK cells, revealing new adherens junction components and their overlap with other junctions.

The paper identifies 29 genes regulating testis morphogenesis through a reverse-genetic screen in Drosophila, revealing roles for dPix and its partners in collective cell migration and organ shaping.

This study investigates the differential roles of RA1 and RA2 domains in Drosophila Canoe during morphogenesis, showing RA1 is critical for function while RA2 has a more limited role.

This study identifies Scribble and Discs-large as critical for positioning adherens junctions and establishing apical-basal polarity during Drosophila embryogenesis.

This paper investigates how Wnt signaling affects the localization, molecular size, and activity of the beta-catenin destruction complex in Drosophila embryos, revealing new insights into complex regulation.

This paper identifies mechanisms by which Rap1 regulates Canoe/Afadin localization and adherens junction positioning to establish apical-basal polarity in Drosophila embryos.