Wnt/β-catenin signaling in development and cancer

The paper shows that β-catenin modulates TCF/LEF binding at gene targets, switching from inhibitory to activating complexes during nephron progenitor cell differentiation.

The paper screens a chemical library to identify environmental chemicals that modulate Wnt signaling, finding diethanolamine as a stimulator with potential for prenatal exposure.

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

This study investigates caspase cleavage of Drosophila Sgg-PD proteoforms, revealing their role in cytoskeletal and cell junction regulation and unexpected retention of cleaved N-terminal domains.

The paper investigates how Wnt3 spreads in the zebrafish brain through diffusion and molecular interactions, showing its binding to HSPG and Lrp5.

This study identifies R-spondins as BMP receptor antagonists, showing they inhibit BMP signaling via ZNRF3 and regulate dorsoventral axis formation in Xenopus embryos.

This study shows that alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling by repressing target gene promoters and interacting with TCF7L1.

This study identifies a feedforward circuit between WSB1 and c-Myc that promotes cancer development through β-catenin signaling, suggesting a potential therapeutic target.

The paper identifies Sox17 and β-catenin interactions at enhancers that regulate endoderm gene expression and repression of mesectoderm fates during Xenopus gastrulation.

The paper shows that Wnt ligands are not essential for Planar Cell Polarity (PCP) in Drosophila wings, as PCP remains normal in the absence of Wnt signaling.

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.

This study identifies HAS-7, an astacin proteinase, as a Wnt processing factor that regulates head formation in Hydra by controlling Wnt ligand activity and axis patterning.

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.

The paper characterizes protein isoforms of the Drosophila sgg gene, revealing distinct localization, interactions, and functions for different proteoforms during development.

This study shows Nanog represses maternal β-catenin activity by interfering with TCF factors, preventing hyper-dorsalization in early embryos.

This paper describes a novel Axin2 knock-in mouse model that visualizes and traces WNT/CTNNB1 responsive cells through fluorescent reporting and lineage tracing.

This study uses single-molecule imaging to analyze Dvl2 dynamics and oligomerization during Wnt pathway activation, showing increased oligomerization and dwell time upon Wnt3a stimulation.

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.

This study shows ADNP is essential for neural differentiation by maintaining Wnt/β-catenin signaling, and its disruption causes neural developmental defects in mice and zebrafish.

This study identifies FZD10 as a receptor for Wnt1 in spinal cord development, showing it regulates neurogenesis and proliferation, but requires Lrp6 for full activity.

This study investigates whether Wnt ligands are required for planar cell polarity in Drosophila wing and notum, finding no evidence supporting their role.

This study shows Lgr5 regulates extracellular matrix production in fetal intestinal stem cells, affecting their maturation and niche environment.

The paper investigates the functional redundancy and additivity of four Lef/Tcf transcription factors in lung epithelial progenitors using genetic knockout models in mice.

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.

The paper examines variability in β-catenin pulse dynamics during a stochastic cell fate decision in C. elegans and links BAR-1 pulse timing to cell fate outcome.

This paper shows that APC-/- tumors in Drosophila disrupt EGF feedback by inducing Rho in both neighboring and tumor cells, leading to chronic EGF signaling and cancerous overgrowth.

This study shows androgen signaling modulates canonical Wnt activity in prostate basal stem cells, maintaining their multipotency by suppressing Wnt-driven differentiation.

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.