Wnt/β-catenin signaling in development and cancer

The paper develops an agent-based model to study the interaction between Hippo and Wnt signaling pathways in intestinal crypts, showing Hippo reduces β-catenin and slows crypt turnover, and division-based Wnt spreading can form gradients.

The paper identifies tcf7l2 splice variants that mediate repressor functions in eye formation by interacting with Tle co-repressors and phosphorylated residues.

This study identifies ΔN-Tp63 as a key mediator of Wnt/β-catenin signaling in basal stem cells of mucociliary epithelia, showing its role in inhibiting differentiation and promoting hyperplasia.

This study shows that umbelliprenin inhibits gastric cancer cell migration and growth by disrupting the Wnt signaling pathway.

The paper identifies PI4K2β as a PAR-1 substrate that inhibits both canonical and non-canonical Wnt pathways, contrasting with PI4K2 which only affects canonical signalling.

The paper investigates how TGFβ ligands alter WNT/{beta}-catenin signaling dynamics during human pluripotent cell differentiation, showing a shift from transient to sustained responses.

This study shows that Iduna regulates Axin proteolysis, which controls stem cell proliferation and intestinal homeostasis in Drosophila.

This study identifies the role of Wnt/Fgf crosstalk in tracheal basal progenitor cell specification through genetic ablation experiments in mouse models.

The paper shows that Wg spreads up to eleven cell distances in Drosophila wing epithelium and that cells outside this range rely on Frizzled2 for target gene expression.

The paper shows that aerobic glycolysis increases intracellular pH in tail bud cells, promoting β-catenin acetylation and Wnt signaling, which drives mesodermal fate over neural fate.

The paper models the interaction between p24-GOLD domain and Wnt8, suggesting a lectin-like binding mechanism and potential decoy-like quenching of Wnt signaling.

This study identifies PDI-1 as a key factor in Wnt protein secretion in C. elegans and shows its conserved role in human cells.

This study identifies a direct link between SP1 and β-catenin in the Wnt signaling pathway, showing their mutual stabilization and role in target gene expression.

The paper shows EGFR is required for Wnt9a-Fzd9b signaling specificity in HSPC development, identifying key domains and phosphorylation events.

This paper investigates how Wnt signaling affects the localization, molecular size, and activity of the beta-catenin destruction complex in Drosophila embryos, revealing new insights into complex regulation.

This study shows RSPO2 and RSPO3 can enhance WNT/β-catenin signaling without LGR receptors, while RSPO1 and RSPO4 cannot, revealing two distinct RSPO signaling mechanisms.

The paper investigates how Wnt/beta-catenin signaling in neighboring cells affects transcriptome heterogeneity and proliferative fate in mouse keratinocytes.

The paper combines optogenetics and light-sheet microscopy to study Wnt signaling in Drosophila embryos, showing light-induced inhibition of Wnt signaling and its role in development.

The paper develops an in vivo Drosophila assay to distinguish Wnt pathway transcriptional responses, identifying gene sets regulated by β-catenin, TCF, and non-canonical Wnt4.

This study identifies RAPGEF5 as a regulator of β-catenin nuclear transport through Wnt signaling, independent of canonical import mechanisms.

The paper uses sensitivity analysis on computational models of the Wnt β-catenin transcription complex to explore psychophysical laws and gene-gene interactions in normal and tumor samples.