Telomeres, Telomerase, and Senescence

The paper proposes a model of senescent cell subtypes transition and identifies a molecular circuit involving NOTCH1 and C/EBPβ that mediates phenotypic switching between beneficial and deleterious senescent states.

This study models how senescence spreads between cells and finds that differences in secreted signalling molecules and timedependent paracrine signalling limit its spread.

This study shows that lack of apoptosis in Drosophila epithelial cells leads to senescence and tumorigenesis, with tumorigenic potential depending on cell identity and JNK pathway activation.

The paper identifies ELG1 as a gene affecting telomere length in yeast and shows SUMOylated PCNA regulates telomerase activity through interactions with the CST complex.

The paper maps de novo telomere addition hotspots in yeast using a high-throughput method and computational analysis, showing enrichment in subtelomeres and Cdc13 binding.

This study identifies EXD2's role in regulating ALT telomere repair pathways by processing replication forks, revealing its importance in cancer survival and potential as a therapeutic target.

The paper investigates how senescence affects the integrated stress response and secretory phenotype in human cells, finding that translational repression of ATF4 reduces stress response and enhances inflammation.

The paper shows that OGG1 and MUTYH repair activities are required for telomeric 8-oxoguanine-induced cellular senescence, with their loss reducing senescence and telomere dysfunction.

This study shows that senescent cells promote muscle dedifferentiation and enhance newt limb regeneration through secreted factors and the FGF-ERK signaling pathway.

The paper identifies POU2F2 and chromatin scars as mechanisms enabling escape from oncogene-induced senescence and their potential as biomarkers in colorectal cancer.

This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.

The paper identifies the interactome of TERT in Trypanosoma brucei using mass spectrometry, revealing unique telomerase interactions in this parasite.

The paper shows DNA-PK and TRF2 inhibit MRN resection at blunt telomeres, preventing fusion through alternative end joining.

The paper shows that early-life telomere length varies across bird species and correlates with life-history traits and chromosome length.

The paper shows that deleting MEC1 suppresses replicative senescence in cdc13-2 yeast cells, which is dependent on telomerase activity.

The paper investigates the existence of SALNR, a putative lncRNA, in senescence models and finds that it may not be an independent transcript but rather a predicted HELLS isoform.

The paper identifies de novo telomere addition at a hotspot near SUL1 in yeast under sulfate-limiting conditions, stabilizing linear amplicons and contributing to genomic plasticity.

The paper finds that wild Saccharomyces cerevisiae isolates have shorter telomeres than domesticated ones, linked to genetic and metabolic differences.

The paper analyzes POT1 variants in a melanoma case-control cohort, finding that pathogenic variants are a minor contributor to melanoma risk but should be screened in high-risk individuals.

This study evaluates how DNA extraction methods and lab factors affect qPCR-based telomere length measurement precision across multiple labs.

The paper identifies telomerase RNA (TR) in Hymenoptera, finding they are short snRNA-like, transcribed by RNA polymerase III, challenging previous assumptions about TR evolution in animals.

The paper shows that POT-3 binds the telomeric G-overhang and has distinct sequence selectivity compared to POT-2.

The paper integrates mass-spectrometry-based metabolomics and proteomics to identify molecular sub-phenotypes of senescence induced by different stressors.

This study investigates Set1's role in telomere maintenance through catalytic and non-catalytic functions in yeast, revealing H3K4 methylation-dependent and independent mechanisms.

The paper shows that TERRA RNA-DNA hybrids regulate senescence in yeast survivors by modulating telomere shortening and HDR.

The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.

The paper investigates how varying ERK activity levels influence proliferation in cells undergoing oncogene-induced senescence, finding intermediate ERK activity promotes maximal proliferation.

The paper identifies a common cis-acting motif involved in TPE-OLD, showing RBPJ binding to Alu-like elements at telomeres to regulate gene expression.

The paper identifies key Rap1 amino acid positions that inhibit telomere end fusions, showing longer telomeres are more prone to fusion when these sites are mutated.