Telomeres, Telomerase, and Senescence

This study identifies dihydromyricetin as a natural senotherapeutic agent that targets senescent cells via PRDX2, alleviating age-related diseases like cancer and Alzheimer's.

The paper analyzes telomere length distributions in 100 Saccharomyces cerevisiae strains, revealing diversity influenced by ploidy, subtelomere structure, and Y element content.

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

The paper shows that AtLa1 binds to telomerase RNA in Arabidopsis, similar to LARP7 in ciliates, suggesting conserved RNA biogenesis pathways between plants and ciliates.

This study shows that transplanting ANXA1-negative CD8 naive T cells extends lifespan and improves health in aged mice by reducing senescence.

This study shows that senescence during postpartum mammary gland involution supports tissue remodeling but also promotes tumorigenesis by enhancing tumor-initiating cell plasticity.

This study shows that transient telomere uncapping in yeast causes genomic rearrangements and telomere elongation, with implications for genome stability and evolution.

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

This study shows BAP1 loss drives senescence in uveal melanoma and makes tumors more responsive to senolytics and radiation.

TARPON is a Nextflow pipeline for analyzing telomeres sequenced on Nanopore, providing a user-friendly interface and customizable analysis for various applications.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

The paper identifies TRFL7 as a telomere-binding protein in Arabidopsis, showing it functions similarly to human TRF2 in telomere maintenance.

This paper validates the reproducibility and utility of the p16-3MR mouse model for studying senescent cells across various conditions and discusses its strengths and limitations.

The paper develops a machine learning classifier to identify cellular senescence using single-cell RNA-seq data, finding it outperforms marker-based approaches and reveals new mechanistic insights.

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

This study shows that targeting GD3 ganglioside, a senescence-associated immune checkpoint, improves healthspan and reduces age-related diseases with sex-specific benefits in mice.

The paper identifies structural variations in TP53 that inactivate TCAB1, a telomerase chaperone, and show these variations are prevalent in ALT-positive osteosarcoma tumors.

This study meta-analyzes parental age effects on offspring telomere length across vertebrates, finding a positive human effect but no significant effect in non-human vertebrates.

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

This study adapts a qPCR method to estimate relative telomere length from archived fish scales, finding variation in telomere length across rivers, age classes, and body size in brown trout.

SenSeqNet detects cellular senescence from protein sequences with 83.55% accuracy using a hybrid LSTM-CNN architecture and ESM-2 embeddings.

The paper uses single-cell RNA sequencing and time-lapse imaging to distinguish quiescence and senescence after chemotherapy, revealing a continuum of cell-cycle withdrawal.

The paper investigates how DAXX mutations affect ALT suppression by analyzing their impact on ATRX localization.

This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.

This study shows senescent cells release chromatin components via extracellular particles, activating inflammation in neighboring cells and being present in aged mice.

This study uses Nanopore whole-genome sequencing to show conserved chromosome-specific telomere length patterns across tissues and populations, revealing coordinated regulation and potential disease risk factors.

This study shows that p16INK4A-expressing fibroblasts release small extracellular vesicles that induce paracrine senescence in neighboring cells.

This study identifies SLFN11 as a suppressor of the ALT telomere maintenance pathway, showing its re-expression reduces ALT activity in cancer cells.