Manuel Collado

This study shows that extracellular vesicles from senescent tumor cells are both necessary and sufficient to induce paracrine senescence in neighboring cells.

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

The paper shows that OSKM expression in lung cancer cells induces apoptosis and senescence, limiting tumor growth and reducing tumor burden in vivo.

The paper identifies an enhancer cluster that drives SOX2 overexpression in breast and lung cancer by altering chromatin accessibility and regulatory mechanisms.