Liver physiology and pathology

The paper uses spatial transcriptomics and single-cell data to identify niche-specific molecular signatures and signaling pathways in ALD cirrhosis, highlighting potential therapeutic targets.

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

This study shows COP1 maintains HNF4A function in primary hepatocytes and HepG2 cells but not HuH-7 cells, challenging previous links between COP1 and hepatic tumorigenesis.

This paper introduces a semi-automated protocol for isolating multiple liver cell types from mouse and human livers with high yield, purity, and viability.

This study shows LARP6 regulates fibrogenic gene translation in liver fibrosis by interacting with collagen mRNAs and reducing fibrosis in human HSCs.

This study uses single-cell transcriptomics and genetic tools to characterize hepatic duct heterogeneity and plasticity in zebrafish, identifying key molecular markers and functional roles in liver regeneration.

This paper introduces a perfusion-independent method to isolate liver sinusoidal endothelial cells with high purity and throughput, comparable to perfusion-dependent methods.

This study shows gemigliptin reduces succinate-induced ER stress and HSC activation, suggesting it as a potential anti-fibrotic agent for liver fibrosis.

This study develops a personalized digital twin model for liver recovery using gene expression data from LDLT donors to predict individual recovery trajectories.

The paper identifies dysregulated RNA splicing in alcohol-associated liver disease as a cause of regeneration failure, highlighting ESRP2 deficiency and its impact on key signaling pathways.

The paper shows that SZN-043, an R-Spondin mimetic, promotes hepatocyte proliferation and Wnt target gene expression in ALD models.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This paper develops a humanized transgenic mouse model for AATD with a SERPINA1-null background, showing liver disease features and supporting its use for studying the disease and drug discovery.

This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.

This study shows that ADAM10's non-catalytic function, not its enzymatic activity, regulates hepatic progenitor cell fate and liver regeneration.

This study shows ADAM17 on myeloid cells drives hepatic DNA damage repair and tumour formation in HCC, suggesting it as a therapeutic target.

This paper develops a rule-based model of hepatic stellate cell dynamics in fibrosis, showing the critical role of inactivation loops in fibrosis progression and identifying inactivated HSCs as markers of fibrosis.

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

This study evaluates Gremlin-1 as a therapeutic target in MASH fibrosis, finding it upregulated but not amenable to targeting due to its restricted expression and lack of effect on fibrogenesis.

This paper develops a hepatic cryoinjury model to study liver regeneration and fibrosis, showing it enables comparison of healthy and injured tissue in the same animal.

This study identifies the ESRP2-miR-122 axis as critical for postnatal liver polyploidization and maturation through RNA processing and cytokinesis regulation.

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

The paper demonstrates that transient mRNA-based growth factor expression in lipid nanoparticles enhances PHH engraftment and liver function in murine liver disease models.

This study develops a method to generate and expand hepatobiliary organoids from adult human hepatocytes, which retain liver function and can model liver diseases.