Aortic aneurysm repair treatments

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

This study evaluates the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm compared to current strategies.

This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

This study uses multiplexed imaging to analyze immune and stromal cell changes in abdominal aortic aneurysms (AAAs) based on C-reactive protein (CRP) levels, revealing distinct immune cell distributions and macrophage phenotypes associated with CRP deposition.

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.

This study uses Mendelian randomisation to investigate a causal link between Metformin use and reduced abdominal aortic aneurysm risk, finding a statistically significant association.

The paper develops an m6A-related mRNA signature using multi-omics and machine learning to predict AAA progression and identifies FKBP11 as a key gene.

This study shows NRF2 inhibits abdominal aortic aneurysm (AAA) development by maintaining contractile vascular smooth muscle cell (VSMC) phenotype through miRNA145 regulation.

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

The paper models a microRNA-derived disease network to identify methotrexate as a potential therapy for abdominal aortic aneurysm in mice.

This study shows that GSDMD deficiency prevents aortic rupture in mice induced by AngII or BAPN, without affecting aortic dilation.

This paper identifies attractin as a biomarker for predicting abdominal aortic aneurysm growth using integrated plasma and tissue proteomics.

The paper investigates the association between genetic risk variants and clinical features of abdominal aortic aneurysms using a biobank cohort, finding a weak polygenic correlation with aneurysm diameter but no clear individual variant associations.

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.