Deborah A. Howatt

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

This study shows that Angiotensin II exacerbates mitral valve and left atrial pathology in Fbn1C1041G/+ mice, while AGT inhibition does not alter the phenotype.

This study shows that deleting angiotensinogen in hepatocytes protects mice from diet-induced metabolic disorders even under thermoneutral conditions that mimic human metabolism.

This study shows that AngII infusion worsens aortic pathology in Fbn1C1041G/+ mice, leading to aortic rupture and branch aneurysms.

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

This study shows that cilostazol and sildenafil do not prevent BAPN-induced thoracic aortopathy in mice.

This study shows that PAR4 deficiency reduces atherosclerosis in Ldlr-/- mice, with effects mediated by hematopoietic cells, particularly platelets, and highlights differences in platelet reactivity between apoE-/- and Ldlr-/- models.

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

This study shows that GSDMD deficiency prevents aortic rupture in mice induced by AngII or BAPN, without affecting aortic dilation.