Gilbert R. Upchurch

This study identifies YAP/TAZ signaling in endothelial cells as a key mediator of abdominal aortic aneurysm formation and shows that pharmacological inhibition reduces AAA progression.

This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.

This study shows vitamin D3 deficiency worsens abdominal aortic aneurysm by increasing complement C3a activation, suggesting targeting this pathway could be a new treatment.

This paper shows that PD1/GPR37 signaling in macrophages enhances efferocytosis, reducing inflammation and preventing AAA formation and rupture.

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

This study examines temporal changes in extracellular vesicle (EV) protein cargo in burn-injury patients and mice, showing distinct immune reprogramming effects at early and late post-injury stages.

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

This paper develops a novel mouse model of ascending aortic dissection and shows that Gsdmd deficiency reduces dissection severity by modulating cell death and T-cell responses.

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.