Renin-Angiotensin System Studies

The paper examines how chronic ethanol exposure affects ACE2 and TMPRSS2 expression in specific brain regions, suggesting increased vulnerability to SARS-CoV-2 neuroinvasion.

This paper performs a meta-analysis of ACE I/D polymorphisms in centenarians and long-lived individuals, finding a positive association of the DD genotype with longevity but not the ID genotype.

The paper examines the effects of maternal captopril treatment on renin expression and granule formation in fetal and newborn mouse kidneys, finding increased granulation without changes in active renin content.

This study investigates how angiotensin II modulates the A-type K+ current in PVN neurons via the MAPK-ERK pathway in rats with heart failure.

This study identifies miR-339-3p as a key regulator in AT1-AA-induced vascular inflammation by downregulating BKα protein expression through the miR-339-3p/NEDD4L axis.

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

The paper analyzes the molecular evolution of AT1 and AT2 receptors across species, showing specific sodium binding site mutations in amniota that affect receptor specificity for angiotensin II.

This study shows SARS-CoV-2 binding to ACE2 on pericytes enhances angiotensin II-induced cerebral capillary constriction via AT1 receptors, suggesting AT1 blockers may mitigate brain blood flow reduction in infection.

The paper identifies renin-expressing B-1 lymphocytes that control bacterial infections by releasing renin and phagocytosing bacteria, linking renin's endocrine role to immune defense.

The paper identifies interferon-induced upregulation of the short ACE2 isoform (dACE2) in renal proximal tubule cells and links it to JAK/STAT pathway activation.

The paper identifies zebrafish orthologs of the RAAS system and shows they are expressed in a specific intestinal cell type relevant to COVID-19 comorbidities.

This study investigates whether renin-angiotensin inhibition affects ACE2 and TMPRSS2 expression in mice, finding no changes in ACE2 but a decrease in TMPRSS2 in lungs with AGT depletion.

The paper examines ACE2 expression in kidney cells in relation to RAAS blockers and age/sex, finding age-related differences and associations with drug use.

This study shows that valproate downregulates Agtr2, Mas1, and Agrt1b in rat lungs, an effect reversed by liraglutide.

The paper examines cell-type-specific expression of RAS components across 141 cell types using scRNA-seq and links ACE2 expression to SARS-CoV-2 infection mechanisms.