Bacteriophages and microbial interactions

The paper determines the near-atomic structure of the P-SSP7 virion and identifies five rotational registers defining modular portal-capsid assembly.

The paper quantifies phage interactions with prokaryoplankton in the tropical ocean, revealing non-infective associations and genetic exchange between phages.

The paper identifies and characterizes a novel Crassvirales phage infecting Segatella copri from Egypt, showing amber stop codon reassignment and geographic diversity.

This study characterizes a bacteriophage, Curly, against Klebsiella pneumoniae, showing its efficacy in reducing bacterial burden and inflammation in human cells and a mouse model.

The paper elucidates the molecular mechanism of the Avs2-trypsin-MBL system, revealing how phage terminase recognition triggers tetramerization and activation of the system for anti-phage defense.

The paper introduces UHVDB, an updateable human virome database and toolkit, and demonstrates its utility in analyzing oral/airway samples from Cystic Fibrosis patients.

The paper identifies five new dicistroviruses infecting green algae, expanding the known host range of the Dicistroviridae family beyond arthropods.

PhageLysData is a curated, AI-ready dataset of phage lytic enzymes and depolymerases, providing annotated sequences, structural data, and embeddings for machine learning applications.

This study investigates prophage induction in human gut metagenomes in response to ciprofloxacin, finding species-specific increases in prophage-to-bacterial host read depth ratios.

The paper identifies structured RNA motifs and Aca proteins that regulate anti-CRISPR gene expression in bacteriophages, revealing new regulatory mechanisms beyond DNA-binding HTH regulators.

The paper characterizes 45 novel bacteriophages infecting ammonia-oxidizing bacteria, revealing their taxonomic diversity and functional roles in nitrification.

This study shows that phage resistance evolution is driven by ecological factors like competitive interactions and fitness costs, not mutation rates, and depends on phage and host concentrations.

This study reveals that phage T7 kinase broadly phosphorylates host and phage proteins, disabling bacterial defense systems through widespread phosphorylation.

The paper identifies old-like genes in certain aquatic eukaryotes, suggesting a potential antiviral defense system evolutionarily related to prokaryotic anti-phage systems.

The paper develops a six-phage cocktail that effectively controls bacterial leaf spot in lettuce and improves harvest quality through field trials.

The paper constructs a comprehensive ESKAPE virome resource, revealing phages' dual roles in targeting pathogens and limiting resistance spread through antagonizing plasmids and ARGs.

This paper presents an integrative structural analysis of the bacteriophage Ar-KM, revealing structural polymorphism and the role of ejection proteins in genome ejection.

The paper analyzes the defensome of Pseudomonas aeruginosa across clinical datasets, finding that multidrug-resistant isolates have more defence systems while cystic fibrosis isolates have fewer, with implications for phage therapy.

PhaGAMeToo merges functional annotations from phage genomes and generates submission-ready GenBank files using Pharokka, VIBRANT, and BLASTP.

This paper introduces the Sustainability Index (SusI) to quantify the duration of phage-mediated bacterial growth suppression and demonstrates its utility in evaluating phage efficacy.

This paper constructs a phage-bacteria interaction atlas for Klebsiella pneumoniae and develops a genome-guided machine learning model to predict phage-host interactions, outperforming traditional methods.

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

This study shows how osmotic conditions influence co-evolution between E. coli and T4 phage, with different resistance mechanisms emerging under varying osmolalities.

The paper identifies viruses and proviruses associated with Asgard archaea and reveals virus-mediated interactions with bacteria, expanding understanding of microbial symbiosis in eukaryogenesis.

The paper uses stable isotope probing to identify active soil viruses involved in carbon cycling, finding that viral lysis is influenced by carbon availability and microbial growth traits.

The paper identifies PanDA, a bacterial defense system that uses a minimal diadenylate cyclase to detect phage evasion by sequestering c-di-AMP, leading to membrane permeabilization.

The paper identifies a bacterial anti-phage defense system called Panoptoo, which uses DAC enzymes to synthesize nucleotide signals that counteract phage immune evasion.

This study re-examines pseudolysogeny in phage T3 and T7 under nutrient limitation, finding that both show impaired propagation, and that T3's reported latent state could not be reproduced.

This paper develops a single-step chromatography method to purify Pseudomonas aeruginosa phages with high endotoxin reduction and protein impurity removal, suitable for therapeutic use.

This paper describes the isolation and characterization of the first cultivated chrysophyte-infecting virus, ChrysoHV, which encodes a proteorhodopsin not previously found in viral genomes.