Tendon Structure and Treatment

This study compares atelocollagen and growth factors in upregulating tendon healing markers in myoblasts, finding AC more effective in enhancing protein expression and cell proliferation.

This study develops a method to quantify subtendon sliding in the Achilles tendon using ultrasound and electrical stimulation, finding differential displacement patterns based on stimulated muscle.

The paper identifies CX3CR1+ monocytes/macrophages as key drivers of impaired healing after ACLR and suggests they are potential therapeutic targets.

This study injects uncultured autologous adipose-derived regenerative cells into rabbit Achilles tendon defects and finds improved biomechanical properties compared to sham treatment.

This study investigates sex differences and the roles of estrogen and progesterone in tendon extracellular matrix remodeling using an explant model of mouse tendons.

This study investigates how inflammation affects tendon fibroblast mechanotransduction by analyzing NF-κβ and JAK/STAT signaling pathways and their interaction with mechanical loading.

This paper introduces a biomimetic soluble collagen scaffold that regenerates a 2 cm Achilles tendon defect in rabbits with 80.1% mechanical recovery and no immune response.

This study uses an ex vivo laser-induced microdamage model to show that tendon cells can clear microdamage regardless of size, with larger injuries showing more robust clearance over time.

This study examines mechanical forces during murine tendon development, finding that increased movement correlates with upregulation of Scx and Tnmd.

This study investigates how glucose and glutamine metabolism changes with aging in tendon tissue and its impact on extracellular matrix remodeling.

The paper examines nuclear phenotypic changes in migrating tenocytes from rat tendon explants over time, finding differences in chromatin features but not DNA methylation or acetylation.

This study shows that mTORC1 and STAT3 signaling are essential for TGFβ1-induced 3D tendon construct formation in vitro.

This study shows that human adipose stromal cells cultured in a minimal 3D system develop a tendon-like phenotype with altered mechanical properties over time.

This paper investigates the structure and mechanics of the sheep calcaneal enthesis to inform scaffold design for tissue engineering.

This study uses single-nucleus RNA sequencing to analyze early cellular changes in human quadriceps tendons after rupture, identifying key cell types and pathways involved in the injury response.

The paper identifies force-responsive genes in zebrafish tendon fibroblasts during embryonic muscle contraction using bulk RNA sequencing.

This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

This study shows AMPK1 is essential for tendon health, preventing senescence and calcification through metabolic regulation and ECM remodeling.

This study shows that tendon inversion improves bone tunnel healing in rats by disrupting the epitendinous surface and enhancing collagen alignment and tensile strength.

This study shows that electrical muscle stimulation improves tendon healing and muscle recovery after Achilles tendon rupture, while static stretching has no additional benefit.

This study shows that actin polymerization status regulates tenocyte homeostasis via MRTF, affecting genes like Type I Collagen and Tenascin C.

This study shows that loss of Cochlin leads to structural and functional impairments in tendons, highlighting its role in maintaining tendon homeostasis.

The paper shows that embryo movement is essential for tendon maturation in chick embryos, with YAP signaling and collagen alignment responding to mechanical cues.

This study shows that temporarily blocking Ccr2+ cell recruitment during the late inflammatory/early proliferative phase improves tendon healing mechanics, while blocking during the acute phase has no effect.

This study estimates Achilles tendon twist in vivo by stimulating individual triceps surae muscles and analyzing ultrasound displacement patterns.

This study assesses the impact of dynamic ultrasound on running patterns and muscle-tendon junction tracking during running, finding minimal effects on running and acceptable reliability for tendon strain measurement.

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

The paper uses stable isotope labeling and mass spectrometry to show that tendon ECM has circadian and permanent pools with distinct turnover rates, which change with age.

The paper identifies proteins from MRL/MpJ mouse tendon ECM and secretome that promote pro-regenerative tenocyte behavior in scar-mediated cells.