Virology and Viral Diseases

This paper develops a reproducible method to generate Nipah virus pseudovirions with uniform F and G glycoprotein expression for high-throughput neutralization assays.

This study identifies an evolutionary distinct N-glycosylation site in Nipah virus G that contributes to receptor binding stability through hydrogen bonding networks.

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

This study identifies Langya virus Korea (LayV KOR) in shrews in South Korea, showing 80% and 95.5% homology to the Chinese strain at nucleotide and amino acid levels.

The paper identifies six divergent morbilliviruses in Neotropical bats and NHPs, showing their role in evolutionary diversification and potential zoonotic risk.

This paper develops a bispecific antibody that targets both Nipah virus surface glycoproteins, reducing viral escape and enhancing protection against NiV disease.

This study presents cryo-EM structures of Nipah virus RdRp in apo and early elongation states, revealing its architecture and RNA interaction mechanisms.

This study compares immune responses in goats infected with high and low virulent PPRV strains, finding strain-specific differences in early inflammation and lymphocyte suppression.

This study investigates how morbilliviruses use SLAM receptors across species, finding that most can use multiple SLAMs except human SLAM, and that MV adapts to bat SLAM with a single mutation.

This study develops a hybrid pseudovirion for rapid nAB quantification against Nipah virus, showing good correlation with PRNT in BSL-2 conditions.

This study characterizes monoclonal antibodies against Nipah virus G-head nanoparticle, identifying neutralizing mechanisms and epitopes that could inform vaccine and therapeutic development.

The paper quantifies RNA editing efficiency in paramyxovirus-infected cells using nanopore sequencing, revealing differences in editing between Sendai virus and canine distemper virus.

This paper shows NiV matrix protein uses cortical actin to stabilize assembly sites and promote budding through interactions with the Arp2/3 complex.

This study investigates how Micafungin inhibits Pteropine orthoreovirus by targeting p17 and modulating IL-6 in host cells.

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

The paper develops a minigenome assay to study Oz virus RNA synthesis and finds that Segment 5 has lower promoter activity due to a partial lack of the distal duplex structure.

This study reports cryo-EM structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody, revealing conformational changes and epitope details.

This study identifies SLC35A2 as a host factor essential for paramyxovirus fusion during infection, showing its role in virus-cell and cell-to-cell fusion events.

This paper identifies two host pathways, epithelial-to-mesenchymal transition and live cell extrusion, that facilitate the detachment of MeV-infected cell clusters from human airway epithelia, enhancing viral transmission.

This paper designs and constructs a synthetic VSV genome, demonstrating its utility for engineering viral properties and gene order rearrangements.

This paper develops tetracistronic minigenomes for henipaviruses to model their life cycle outside high biocontainment, revealing Cedar virus replicase promiscuity and functional GhV replicase with antiviral efficacy.

This study identifies how paramyxovirus matrix proteins inhibit host cell translation by interacting with the exon-junction complex, enhancing viral replication.

This study shows Chandipura virus forms cytoplasmic inclusion bodies through phase separation involving PKR and TIA-1, evading antiviral stress granules and enhancing viral replication.

This paper describes an efficient plasmid-based system for producing recombinant VSV encoding foreign glycoproteins, validated with glycoproteins from multiple viral families.

The paper reports the cryoEM structure of Hendra henipavirus nucleoprotein bound to RNA, revealing unique interactions in its multimeric assembly and insights into paramyxoviral nucleocapsid architecture.

This paper develops minigenome systems for Nipah and Hendra viruses and shows that their polymerase complex proteins can replicate both minigenomes regardless of origin, suggesting potential targets for antivirals.

This study identifies species-specific interactions between Newcastle Disease Virus proteins and mucins in chickens and quails, highlighting potential targets for vaccine development.

This study uses single-molecule microscopy to show NiV-F forms nanoclusters on membranes, which promote fusion by enabling interactions with the NiV-G/receptor complex.

This study identifies genetic variations in BoDV-2 that enhance its growth and reveals its ability to maintain genomic polymorphisms in infected cells by lacking superinfection exclusion.