melanin and skin pigmentation

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

The paper identifies ciliary proteins that regulate melanogenesis in melanocytes and reveals moonlighting roles for Joubert Syndrome proteins in endolysosomal organization.

This study shows extracellular Granzyme B contributes to vitiligo by causing melanocyte detachment, senescence, and abnormal epidermal differentiation, and identifies it as a therapeutic target.

The paper isolates and characterizes a new class of soluble melanin from fungi, showing it forms nanoparticles and arises through convergent evolution.

This study identifies transcriptomic differences underlying color variation in bluefin killifish, revealing genes involved in pigment pathways and light-sensitive phenotypic plasticity.

This study identifies ellagic acid from Corynebacterium amycolatum SB-1 as a bioactive compound with anti-melanogenic and collagen-promoting effects on skin cells.

This study disrupts optix in Manduca sexta and finds it regulates abdominal pigmentation, replacing orange with black eumelanin, suggesting optix modulates an alternative pigment pathway.

The paper shows how epigenetic coalitions in birds couple tissue growth to generate periodic color patterns through ASIP regulation and feedback loops.

This study identifies melanogenesis gene mutations that alter feather photonic nanostructures, causing iridescent color changes in peafowl and wild birds.

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

The paper develops a physics-based framework to link skin chromophore content to colorimeter-derived skin color coordinates, revealing how melanin and blood contribute to the banana-shaped locus in CIELAB space.

This study shows that reducing sAC activity restores pigmentation in OCA models and increases melanin synthesis, suggesting targeting melanosome pH as a therapeutic strategy for OCA and skin cancer risk.

This study identifies the ivory:mir-193 locus as a major determinant of melanic color variation in Anticarsia gemmatalis moths, showing that divergent haplotypes and regulatory elements control dark morph pigmentation.

This study quantifies peri-iridal brightness in terrestrial non-primate mammals and finds that photoprotective demands, eye size, and ecology significantly influence ocular pigmentation.

The paper compares subjective skin color categorization methods with objective spectrophotometer measurements and proposes a new standardized system for better representation and application in healthcare and research.

The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.

The paper investigates coat color variation in Hungarian Puli dogs and finds evidence of incomplete dominance of the Ay allele over the a allele, linked to MC1R gene variants.

This study characterizes hair follicle and epidermal melanocytes, showing hair follicle melanocytes survive and proliferate after UVB irradiation, while epidermal melanocytes die, and links these findings to vitiligo treatment.

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

The paper shows how graded BMP signals influence pigment cell development and color in fish, affecting adult patterns and behavior through conserved mechanisms.

This paper introduces a functional rescue assay to classify genetic variants in albinism genes, demonstrating its effectiveness with TYR variants.

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

This study investigates RD-induced melanocyte loss in guinea pigs, finding basement membrane disorganization and MMP2 activity contribute to melanocyte detachment and depigmentation.

The paper identifies a gene involved in pigment cell communication that governs color pattern formation in zebrafish and anemonefish.

This paper identifies additional genetic markers influencing eye color in individuals with genotypes not matching their expected phenotype based on rs12913832.

The paper identifies ttc39bl as the gene responsible for carotenoid coloration in medaka, showing a mutation in the X chromosome causes white body color.

This study investigates the genetic basis of vertical bar evolution in clownfish by analyzing changes in selective pressure on pigmentation-related genes.

This study shows that the p300 inhibitor A-485 reduces melanin production in human melanocytes by decreasing MITF and DCT expression.

This study evaluates melanocyte stem cell and immune cell changes in vitiligo patients before and after narrow-band UVB phototherapy, finding increased MelSC re-population and reduced CD3+ T-cells.