Toxoplasma gondii Research Studies

The paper uses a CRISPR/Cas9 screen to identify type I interferon-stimulated genes that regulate Toxoplasma gondii infection in macrophages.

The paper identifies a unique Toxoplasma gondii haplotype associated with domestic cats and shows it has been selected for its role in sexual reproduction in domestic cats during their global expansion.

The paper reports a novel fragmented mitochondrial genome in Toxoplasma gondii and related tissue coccidia, revealing a unique genome architecture and cytochrome gene structure.

The paper reevaluates the genomes of Toxoplasma gondii and Neospora caninum, revealing misassembly, chromosomal rearrangements, and new genes, with implications for genome-based comparative biology.

This paper uses third-generation sequencing to revise the molecular karyotype of Toxoplasma gondii, identifying chromosome fusions and copy number variants in sexual recombinants.

The paper identifies ROP33 as a murine virulence gene in Type X Toxoplasma gondii strains isolated from southern sea otters, showing differential pathogenicity across hosts.

This study investigates the effects of Toxoplasma gondii infection on a 3D human brain model, showing changes in morphology, gene expression, and inflammation.

The paper uses single-cell RNA sequencing to show that CD16- monocytes are key in the transcriptional response of human monocytes to Toxoplasma infection, revealing transcriptional heterogeneity and cytokine secretion patterns.

The paper investigates the association between KIR gene polymorphism and recurrence rates of ocular toxoplasmosis in Brazilian patients, finding protective and susceptibility markers.

The paper uses RNA-seq to compare transcriptional profiles of neurons infected with Toxoplasma gondii, bystander neurons, and controls, finding immune cell transcripts enriched in infected neurons.

This study shows that Toxoplasma gondii infection causes loss of perisomatic inhibitory synapses through microglia-mediated synaptic stripping.

This study shows that endocytosis is essential for gliding motility in Toxoplasma gondii, as it enables retrograde membrane flow and the recycling of surface proteins.

This study examines how chronic Toxoplasma gondii infection affects social behavior and neural circuits in female mice, identifying molecular changes in brain regions associated with social behavior.

This study shows that latent Toxoplasma gondii infection worsens neurodegeneration in YAC128 HD mice by increasing soluble mutant huntingtin and neurofilament light protein levels.

This paper engineers Toxoplasma gondii to deliver therapeutic proteins to the CNS by fusing them to the parasite's secretory proteins, demonstrating potential for intracellular delivery of treatments for neurological disorders.

This study shows that Toxoplasma gondii infection of radial glia cells reduces their proliferation and neurogenesis, disrupts endothelial cell barrier function through cytokine changes, and impairs neurovascular interactions.

The paper investigates associations between toxoplasmosis and borreliosis infections and psychiatric disorders in 46,000 subjects, finding stronger links with toxoplasmosis for several mental health conditions.

The paper compares physical and mental health status of Toxoplasma-infected and uninfected women before and three years after infection disclosure, finding poorer health in infected women regardless of Rh factor.

This study investigates how Toxoplasma gondii infection alters host transcriptional regulation by redistributing AP-1 transcription factor binding, leading to changes in chromatin accessibility and gene expression.