Anita A. Koshy

This study identifies two copper transporters in Toxoplasma gondii and shows their roles in parasite metabolism and persistence.

The paper compares neuronal transcriptional responses to Toxoplasma gondii and RNA viruses, identifying conserved and pathogen-specific immune responses in neurons.

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

This study investigates the role of Toxoplasma gondii type II effector GRA15 in vivo, finding it has a limited impact on brain parasite burden and immune cell numbers at 3 weeks post-infection.

The paper shows that chronic Toxoplasma gondii infection reduces the cytotoxic response of T cells to West Nile virus in the brain, increasing susceptibility to WNV.

This paper introduces dual perturb-seq, a method combining CRISPR screening and single-cell RNA-sequencing to identify host-microbe transcriptional interactions, revealing new effector proteins in Toxoplasma gondii.

This study shows that IFN-γ stimulated murine and human neurons can clear Toxoplasma gondii parasites, challenging the dogma that neurons cannot mount anti-parasitic defenses.

The paper uses RNA-seq to compare transcriptional profiles of neurons infected with Toxoplasma gondii, bystander neurons, and controls, finding immune cell transcripts enriched in infected neurons.