3D Printing in Biomedical Research

The paper develops a Bronchial Airways-On-Chip system using iPSC-derived bronchial epithelium to assess cytokine secretion from low-dose, long-term exposure to benzene, showing accumulative effects and reversibility with Montelukast.

This paper presents a robust fabrication protocol for elastic porous PDMS membranes used in organ-on-a-chip systems, improving reproducibility and reducing failure rates.

This paper introduces 3D printed bioelectronic scaffolds for impedance-based cytotoxicity monitoring in 3D cancer cell cultures, demonstrating their effectiveness in drug response assessment.

This paper develops a microfluidic platform for 3D tumor-stroma co-cultures that stabilizes ECM and supports long-term drug testing with high-content imaging and AI analysis.

The paper introduces a thyroid-on-chip platform using mouse embryonic stem cell-derived thyroid organoids to dynamically screen endocrine disrupting chemicals (EDCs) and identify molecular signatures of thyroid disruption.

The paper introduces GEM multinozzle printheads to accelerate ink formulation by enabling parallelized printing and combinatorial ink mixing for complex 3D structures.

This paper develops a heart-on-a-chip device with aligned fibers to assess cardiotoxicity, showing functional responses to drugs and replicating clinical cardiotoxic events.

This paper develops a long-lived human vascular avatar to model age-related vascular disease and aging using iPSC-derived cells.

This paper introduces a modified Hele-Shaw Cell technique to fabricate vascular perfusion phantoms with fractal-like structures, validated for physiological flow and geometry.

This paper develops a method to create vascularized bioartificial organs using 3D printing and polymer casting, demonstrating its application in creating a functional pancreas for diabetes treatment.

The paper develops a Limb-on-a-Chip platform for scalable and reproducible neuromuscular tissue engineering, enabling high-resolution imaging and functional analysis of motor neuron-muscle interactions.

This study evaluates three cell counting assays in 2D and 3D in vitro models, finding that 2D cultures yield more precise and reliable results than 3D ECM-based cultures.

The paper develops a cost-effective alveolus-on-chip to study early Mycobacterium tuberculosis infection, showing macrophages enhance infection susceptibility.

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

This study develops a 3D thyroid in vitro model using microfluidic bioprinting to test endocrine disruptors and assess their effects.

This study develops a geometry-controlled platform to analyze and modulate spheroid compaction kinetics and shape engineering using microwells and computational modeling.

This paper introduces a high-throughput histopathology workflow for complex in vitro models using 3D-printed histomolds, enabling efficient processing and analysis of multiple samples.

This paper introduces a membrane-free alveoli-on-a-chip using biodegradable scaffolds that mimics interstitial mechanics, immune trafficking, and aerosolized mRNA delivery in human alveoli.

This paper evaluates multi-outlet nozzle designs for bioprinting using computational fluid dynamics to determine optimal geometries for different printing tasks.

This paper introduces a generative AI framework for designing and fabricating disease-specific lung microtissues using 3D imaging and bioprinting.

This paper introduces vitamin C as a redox regulator to enable high-fidelity volumetric printing of pristine collagen by establishing a tunable nonlinear polymerization threshold.

The paper develops 3D mammary duct models of healthy and tumoral tissues using a microfluidic co-extrusion platform to better mimic breast tissue architecture and function.

The paper introduces an integrative framework for generating bio-informed microvascular models that unify in silico and in vitro applications, demonstrating faster and more accurate simulations of vascular networks.

This study develops a novel bioink, GelMA-TMA, which enhances muscle tissue regeneration by improving mechanical properties and cell function in 3D-printed scaffolds.

This paper develops patient-specific intracranial aneurysm models using additive manufacturing to study pathophysiology and rupture risk.

This study develops a lymphoid-tissue-on-chip model that recapitulates human antibody responses to influenza vaccines in vitro.

The paper describes a method to create cm-scale perfusable endocrine pancreatic tissues using sacrificial embedded 3D printing in alginate, showing viability and insulin secretion in cultured beta cells.

This study develops an optical system to measure perfusion pressure and flow resistance in microfluidic devices without contacting the fluid, validating its accuracy against hydrostatic methods.

This paper presents a biodegradable lung alveoli-on-a-chip that mimics the human air-blood interface to assess particulate-matter-induced pulmonary toxicity.

This paper introduces a stencil-based method to create 2D microtissue co-cultures with spatial precision, demonstrating applications in tumor microenvironment modeling, morphogen gradient studies, and intestinal architecture recreation.