Neuroinflammation and Neurodegeneration Mechanisms

ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

Changes in microglia chromatin accessibility in aged female mice.

This study identifies age-related changes in chromatin accessibility in female microglia, showing more gains than losses in accessibility, enriched in immune-related genes and intergenic regions.

CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction

This study identifies transcriptional differences between resident and recruited hypothalamic microglia in diet-induced obesity, showing that CXCR3-expressing recruited cells protect against metabolic dysfunction.

DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSE

This study examines how different doses of HDAC inhibitors TSA and SAHA affect glial inflammatory responses to LPS, showing dose-dependent pro- and anti-inflammatory effects.

Interneuron-like features of microglia in the mouse outer retina

The paper identifies microglia in the mouse outer retina as resembling interneurons in other species, suggesting potential interneuron-like functions in vision.

Regional Microglial Response in Enthorino-hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation.

The paper investigates microglial and astrocytic responses to a Schaffer collateral lesion and MMPs modulation in mouse hippocampal slice cultures, revealing region-specific changes.

Extracellular matrix and microglial regulation of cognitive aging

The paper investigates how microglia and the extracellular matrix influence cognitive aging by analyzing ECM composition, microglial interactions, and their relationship with synapses and behavior.

iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype

This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer disease

This study identifies four novel genetic loci associated with soluble TREM2 levels in CSF through GWAS and provides functional validation of their roles in Alzheimer's disease.

Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models

This study evaluates four microglial CreER mouse models to compare their recombination specificity, leakiness, efficiency, extra-neural recombination, and off-target effects in neonatal brain development and injury models.

ATM-deficiency induced microglial activation promotes neurodegeneration in Ataxia-Telangiectasia

This study shows that ATM deficiency causes microglial activation, which contributes to neurodegeneration in Ataxia-Telangiectasia by inducing cytotoxicity in neurons.

Single nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke

This study uses single nucleus RNA sequencing to identify glial cell-specific responses to ischemic stroke, revealing shared transcriptional responses and interactions between oligodendrocyte lineage cells, astrocytes, and myeloid cells.

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states

This study examines microglial phenotypic changes in human and murine cerebral small vessel disease under acute and chronic hypertension, identifying stage-specific morphological and surface marker alterations.

Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis

This study shows that EGCG modulates microglia to reduce inflammation and phagocytosis of Aβ, suggesting therapeutic potential for AD.

Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain

This study investigates the effects of PLCγ2 deficiency in mouse brains using multi-omics approaches, revealing sex-specific changes in lipid and gene expression that may link to Alzheimer's disease and aging.

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function: insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

This study investigates the effects of the PLCγ2 S707Y hypermorphic variant on human microglia, showing increased enzymatic activity but reduced phagocytosis and cytokine production, and suggests therapeutic strategies should mimic the beneficial effects of the P522R variant.

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors

This study shows that microglial β2 adrenergic receptors modulate Alzheimer's disease pathology by reducing inflammation and amyloid pathology in mouse models.

An inducible genetic tool for tracking and manipulating specific microglial states in development and disease

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.

Parkinson's disease-derived α-Synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype

The paper investigates how Parkinson's disease-derived α-synuclein fibrils combined with inflammatory factors drive a neurotoxic microglial phenotype.

Neural crest mural cells of forebrain meninges harbor innate immune functions during early brain development and exhibit different responses to septic and toxic insults

This study identifies CNC mural cells as innate immune cells in the developing forebrain, showing their phagocytic and antigen-presenting capabilities and responses to bacterial and toxic insults.

A Role For Astrocytic Insulin-Like Growth Factor I Receptors In The Response To Ischemic Insult

This study investigates the role of astrocytic IGF-IR in ischemic injury, finding that its deletion leads to larger lesions and worse outcomes.

Investigation of microglial diversity in a mouse model of Parkinson's disease pathology

This study investigates the role of CLEC7A-positive microglia and dark microglia in a mouse model of Parkinson's disease with the LRRK2 G2019S mutation, revealing their association with cellular stress and pathology.

Microglia undergo transcriptional, translational and functional adaptations to dark and light phases in laboratory mice

The paper investigates circadian changes in microglial transcriptional, proteomic, and functional profiles in mice, finding significant differences between light and dark phases and impaired circadian regulation in a neurodevelopmental disorder model.

Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids

This study uses AD organoids to identify dynamic neuroinflammatory profiles and their impact on neuronal health and microglial function.

Temporal and spatial analysis of astrocytes following stroke identifies novel drivers of reactivity

The paper analyzes astrocyte gene expression changes after stroke using spatial transcriptomics and single nucleus RNA-seq to identify novel reactive substates and their functional roles.

Therapeutic targeting of immunometabolism in Alzheimers disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.

This study shows that reducing Hexokinase 2 (HK2) in microglia slows Alzheimer's disease progression, but complete loss worsens inflammation, suggesting a complex role for HK2 in neuroinflammation.

Microglial NF-κB Signaling Deficiency Protects Against Metabolic Disruptions Caused by Volatile Organic Compound via Modulating the Hypothalamic Transcriptome

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's Disease

This study investigates the sex-specific role of Cst7 in microglia in an amyloid-driven Alzheimer's Disease model, finding sexually dimorphic effects on endolysosomal function and inflammation.

Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice

This study shows that TREM2 loss increases parenchymal amyloid-beta but reduces cerebral amyloid angiopathy in Tg-SwDI mice.