Ferroptosis and cancer prognosis

Dual Targeting of BRAFV600E and Ferroptosis Results in Synergistic Anticancer Activity via Iron Overload and Enhanced Oxidative Stress

This study shows that combining BRAFV600E inhibition with ferroptosis induction synergistically kills anaplastic thyroid cancer cells by increasing iron and oxidative stress.

FSP1 and histone deacetylases suppress cancer persister cell ferroptosis

The paper identifies FSP1 and histone deacetylases as suppressors of cancer persister cell ferroptosis and suggests combining GPX4 inhibitors with these targets to eliminate persister cells.

Modelling ferroptosis in a human microglial line by sequential exposure to iron and GPX4 inhibition

The paper establishes a human microglial ferroptosis model using HMC3 cells and identifies dysregulated lipid species and metabolic pathways associated with ferroptosis.

Amino acid restriction sensitizes lung cancer cells toferroptosis via GCN2-dependent activation of the integratedstress response

The paper shows that amino acid restriction increases lung cancer cell sensitivity to ferroptosis by activating GCN2 and the integrated stress response, without affecting glutathione levels.

Mitochondrial ROS-induced metabolic alterations differentially regulate ferroptosis sensitivity

The paper identifies mtROS-induced metabolic changes that regulate ferroptosis sensitivity by affecting glutathione and CoQ biosynthesis in hepatocytes and cancer cells.

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

Oxymatrine Induces Ferroptosis in MKN28 Gastric Cancer Cells

This study shows oxymatrine induces ferroptosis in MKN28 gastric cancer cells by increasing lipid peroxidation and iron levels, and activating ferroptosis-related pathways.

Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in NSCLC

This study shows that GPX4 loss in tumor cells promotes NSCLC by reprogramming lipid metabolism and suppressing antitumor immunity through ferroptosis evasion and immunoinhibitory TME.

Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth

This study shows curcumin analogues HO-3867 and AKT-100 induce HMOX1-mediated ferroptosis and apoptosis, effectively inhibiting endometrial cancer cell growth.

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

Targeting FSP1 triggers ferroptosis in lung cancer

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

Cell size modulates ferroptosis susceptibility

This study shows that larger cells are more resistant to ferroptosis due to higher glutathione levels and lower lipid peroxides.

Lipid peroxidation intrinsically induces mitochondrial iron overload via Bach1-HO-1 signaling to promote cardiac ferroptosis

This study identifies a mechanism by which lipid peroxidation induces mitochondrial iron overload via Bach1-HO-1 signaling, promoting cardiac ferroptosis and dilated cardiomyopathy.

In vivo imaging of ferroptosis through nanodynamic changes in lipid membranes

The paper identifies phosphatidyl serine exposure as a marker for imaging ferroptosis and demonstrates that the dye CJ215 can label ferroptotic cells in vitro and in vivo.

An integrated model of population growth saturation and basal ROS levels predicts cellular ferroptosis sensitivity

The paper models how population growth and ROS levels interact to determine ferroptosis sensitivity, revealing feedback loops and steady states in cellular behavior.

Downregulation of acetyl-CoA carboxylase suppresses the malignant progression of oral cancer

This study shows that reducing ACACA expression suppresses oral cancer growth and enhances cisplatin's effect on ferroptosis.

FOLFIRINOX Combined with GPX4 Inhibition Induces Ferroptosis and Defines Redox-Based Therapeutic Subgroups in Pancreatic Cancer

This paper evaluates combining FOLFIRINOX with GPX4 inhibition to induce ferroptosis in pancreatic cancer, identifying redox-based biomarkers for treatment stratification.

FERROPTOSIS GENE SIGNATURES REVEAL DISTINCT REGULATORY LANDSCAPES IN GASTRIC ADENOCARCINOMA AND OTHER TISSUES

This study identifies distinct ferroptosis gene signatures in gastric adenocarcinoma and adjacent tissues, revealing transcriptional heterogeneity and regulatory imbalances.

Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation

This study shows abnormal shear stress induces ferroptosis in endothelial cells by downregulating KLF6, leading to reduced SLC7A11 and CoQ10 levels and increased lipid peroxidation.

An integrative machine learning approach identifies the centrality of ferroptosis, cuproptosis, and immune pathway crosstalk for breast cancer stratification and therapy guidance.

The paper identifies a four-gene panel using machine learning that captures redox, proliferative, and immune pathway dysregulation in breast cancer, achieving high accuracy in tumor-healthy discrimination.

Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

This study shows that GPX4 inhibitor sensitivity differs between 2D and 3D cultures due to lipid composition changes, with 3D cultures showing resistance through PUFA displacement by MUFAs.

Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance

This study identifies BRG1-driven ferroptosis resistance as a mechanism of BTKi resistance in MCL and shows that BRG1 inhibition restores ferroptotic sensitivity and synergizes with BTKi.

Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect

This study shows FLASH RT increases lipid peroxidation and ferroptosis in tumors but not normal tissues, and high-iron diets negate FLASH's protective effect in normal tissues.

The dietary emulsifier polysorbate-80 induces lipid accumulation and cell death in intestinal epithelial cells via ferroptosis

This study shows that polysorbate-80 induces ferroptosis in intestinal epithelial cells by disrupting lipid homeostasis, leading to cell death and potential contributions to chronic diseases.

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy

This study shows that inhibiting cap-dependent translation in lymphoma cells increases sensitivity to ferroptosis and CAR-T therapy by reducing NRF2 expression.

Thioredoxin Reductase 1 inhibition triggers ferroptosis in KRAS-independent lung cancers

The paper identifies TXNRD1 as a therapeutic target in KRAS-WT and KRASi-resistant lung cancers by showing TRXR1 inhibition induces ferroptosis through redox mechanisms.

Endocrine therapy induces oxidative stress in ER+ breast cancer that sensitizes persister cells to ferroptosis

This study shows endocrine therapy induces oxidative stress in ER+ breast cancer cells, making them more susceptible to ferroptosis, suggesting a new therapeutic strategy.

Regulation of Ferroptosis in Obesity: Muscle Type-Specific Effects of Dietary Restriction and Exercise

This study investigates how dietary restriction and exercise affect ferroptosis in different muscle types during obesity, finding fiber-type-specific regulation through GPX4.

Characterization of the Mechanisms Underlying Sulfasalazine-Induced Ferroptotic Cell Death: Role of Protein Disulfide Isomerase-Mediated NOS Activation and NO Accumulation

This study investigates how sulfasalazine induces ferroptosis via PDI-mediated iNOS activation and NO accumulation in rat cell lines.