Mast cells and histamine

The paper investigates the transcriptional regulation of basophil-specific protease genes Mcpt8 and Mcpt11, identifying C/EBPα, GATA2, TGF-β signaling, and epigenetic factors as key regulators.

The paper uses single-cell RNA sequencing to identify five distinct mast cell subsets in the human colon, revealing layer-specific distribution and functional profiles.

This study shows carnosic acid reduces pro-inflammatory mediator release from mast cells after IL-33 activation, despite increasing intracellular levels of these mediators.

This study shows that FosB/ΔFosB in mast cells regulates gene expression to reduce allergic inflammation in male mice by enhancing DUSP4 expression.

This study investigates the role of PAR-2 in anaphylaxis using PAR-2-deficient and tryptase-deficient mice, finding that PAR-2 protects against anaphylaxis by modulating eNOS activity.

This study identifies the Arp2/3 complex as critical for maintaining mast cell survival and tissue residency through actin-dependent mechano-protection.

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

The paper identifies a genetic modifier locus, Bphse, that complements resistance to histamine sensitization in mice by analyzing Hrh1 alleles and using network-based methods.

This study shows GATA2 regulates mast cell identity and antigen responsiveness by enhancing chromatin accessibility at super-enhancers.