RNA modifications and cancer

This study identifies specific residues in the YTHDF2 IDR that regulate m6A-dependent mRNA decay using base-editor screens.

The paper identifies 21 novel pseudouridine sites in S. cerevisiae tRNAs using DRS and BACS, and maps their modifying enzymes.

This study identifies the m6A-SIRP axis as a regulator of efferocytosis in atherosclerosis, showing myeloid m6A loss increases plaque instability.

This study uses CRISPR interference and Nanopore sequencing to investigate RNA modifications in E. coli, revealing their impact on growth and protein pathways.

This study shows METTL3 promotes human coronavirus replication without requiring interferon signaling.

This study identifies conserved aromatic residues in FTO that recognize the mRNA 5' cap and enhance m6Am demethylation, providing structural insights into FTO's selectivity for m6Am over m6A.

This study shows that m6A methylation stabilizes genes involved in temozolomide resistance in glioblastoma, and inhibiting METTL3 can restore drug sensitivity.

This study uses single-molecule nanopore sequencing to analyze rRNA modifications in human cells, revealing local coordination of modifications and their response to drug treatment.

This study identifies VIRMA as an HCV RNA-targeting factor that recruits the m6A-MTC to the viral genome through a WTAP-independent mechanism.

The paper functionally and structurally characterizes RNA cap methyltransferases from Trichomonas vaginalis and identifies inhibitors targeting these enzymes.

This study maps stress-induced changes in yeast tRNA modifications, revealing stress-specific reprogramming and introducing a metric to separate modification changes from tRNA abundance.

mBACS improves pseudouridine profiling with higher conversion efficiency and lower false positives, revealing new sites and functional insights into tRNA modifications.

The paper identifies C/D box snoRNAs, including orphans, that are involved in fear-related memory processes in mice by modulating mRNA methylation and synaptic function.

This study shows Hakai regulates m6A RNA methylation and immune response in colorectal cancer by interacting with VIRMA and affecting METTL3 localization.

This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.

This study shows that N6-methyladenosine (m6A) is abundant on IAV mRNAs but rare on genomic RNA, and m6A promotes mRNA stability and viral replication.

This study shows temozolomide causes RNA alkylation and widespread translational repression in glioblastoma cells by targeting guanine-rich transcripts.

The paper shows TYLCV co-opts its vector's m6A machinery to enhance reproductive fitness in resistant whiteflies, revealing a mechanism for adaptive virus-vector interactions.

Modtector efficiently extracts RNA modification signals from sequencing data, outperforming existing tools on large datasets.

The paper introduces snoCLASH, a method to identify snoRNA-mRNA interactions, revealing thousands of interactions and validating a target with functional effects on protein expression.

ERFMTDA predicts tsRNA-disease associations by modeling complex feature interactions and using a biologically informed negative sampling strategy, outperforming existing methods.

The paper reveals the structural basis of hDicer-tRNA complex formation and shows that m5C modification facilitates tRNA cleavage by hDicer.

This study uses direct RNA sequencing to show that Leishmania infection remodels the host m6A epitranscriptome, affecting immune and metabolic transcripts.

TriTower-m6Am improves m6Am site prediction by integrating semantic, sequential, and structural RNA features, achieving higher sensitivity than existing methods.

This study shows that FTO regulates morphine reward and tolerance through m6Am methylation of snRNA, without affecting analgesia.

The paper identifies dynamic changes in rRNA modifications during human embryonic stem cell differentiation using Nanopore sequencing and snoRNA profiling.

This study shows that the archaeal Trm14 methyltransferase modifies both m2G6 and m2G67 in tRNAs and that these modifications are important for growth at high temperatures.

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

This study identifies ALKBH4 as an m6A demethylase in whiteflies, showing its role in reversing mRNA methylation and regulating development.