Circular RNAs in diseases

This study identifies 3,447 circRNAs in Camelina sativa, showing their association with lipid metabolism and regulation of gene expression through alternative splicing and miRNA interactions.

This study identifies circCLIP2 as a circRNA overexpressed in glioblastoma stem cells that promotes tumor aggressiveness through EMT and ECM signaling.

The paper systematically screens RNA binding proteins that enhance circular RNA translation and identifies 68 activators, using a machine learning algorithm to predict additional candidates.

This study identifies circAEBP2 as a regulator of dendritic cell development and function, showing its role in promoting maturation and immune activation through interactions with hnRNP F and the NF-κB pathway.

The paper identifies circASH1L(4,5) as a protector of miR-129-5p from degradation, enhancing its stability and function in human skin wound healing.

TERRACE improves circRNA assembly accuracy by using a splice graph and dynamic programming, outperforming existing methods in sensitivity and precision.

This study identifies circSMAD3 as a regulator that suppresses vascular smooth muscle cell proliferation and neointima formation by promoting hnRNPA1 degradation.

KGRACDA predicts circRNA-disease associations by capturing local depth information in a knowledge graph, outperforming existing methods.

The paper introduces CircCNNs, a CNN framework that identifies back splicing motifs in circRNA biogenesis with high specificity and reduced false positives.

The paper identifies pathway-specific functional circular RNAs through loss-of-function screens in cancer cell lines, revealing roles in ferroptosis, WNT, and MAPK signaling.

This study identifies a circRNA_012164/miR9-5p axis that promotes cardiac fibrosis in diabetic cardiomyopathy through regulation of fibrotic gene expression.

The paper introduces vCircTrappist, a bioinformatic pipeline for identifying viral-encoded circular RNAs, and validates its effectiveness using multiple viral families.

The paper identifies glucose-regulated circRNAs in pancreatic β-cells, showing circRabep1 modulates β-cell growth via the miR-335-3p/PTEN axis.

This study shows ELAV regulates neuronal circRNA production by modulating splicing to favor circularization over linear splicing.

Tormentor identifies and annotates Obelisks, circular RNA viroid-like elements found in human gut samples, using RNA-Seq data analysis.

This study identifies circHMGCS1 as a regulator of vascular endothelial dysfunction in diabetes by sponging miR4521, leading to impaired nitric oxide production and increased oxidative stress.

This study identifies reliable circular RNAs in bovine tissues by comparing total-RNAseq and mRNAseq data, revealing many artificial circRNAs and false entries in existing catalogs.

This study identifies a circRNA-miRNA-mRNA network in breast cancer, highlighting potential biomarkers for basal-like breast cancer classification.

The paper describes analytical methods for improving circRNA circularization efficiency through vector engineering and ribozyme optimization.

This study investigates the role of hsa_circ_0001495 in 16HBE cell inflammation caused by combined PM2.5 and O3 exposure, finding it inhibits the inflammatory response.

This study identifies hsa_circ_0001304 as a regulator of VSMC autophagy via the miR-636/YTHDF2/mTOR axis, which promotes neointimal hyperplasia.

CircRNA-Pro detects differentially expressed and translatable circRNAs using integrated algorithms and validation against databases, validated on breast cancer and SARS-CoV-2 datasets.

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.

This study identifies and characterizes multiple circRNAs from the Drosophila scro gene, showing their biogenesis depends on intronic complementary sequences and highlighting Scro's role in regulating both linear and circular RNA production.

The paper introduces CircSite, a deep learning tool that predicts RBP binding sites on circRNAs at single-nucleotide resolution and identifies key binding subsequences.

Cirscan identifies differentially active circRNA sponge mechanisms and visualizes circRNA-miRNA-mRNA networks from transcriptomic data.

This study shows that FTDP-17 mutations affect circTau RNA formation and translation, with ADAR1-p150 editing playing a key role in their expression and function.

The paper identifies m6A-dependent circRNA dysregulation as a causal factor in tau-induced neurotoxicity using Drosophila and iPSC models.

This paper identifies circHIPK3 as a competing endogenous RNA that sequesters IGF2BP2 to regulate target mRNAs, including STAT3, and shows its correlation with bladder cancer survival.

TCCIA integrates circRNA profiles, immunotherapy response data, and clinical outcomes to explore circRNA roles in cancer immunotherapy.