Circular RNAs in diseases

FindBacksplice locates circular RNA backsplice coordinates using BSJ sequences across any genome version and species.

This study shows that circular RNAs accumulate in aged human placental tissue and in stillbirth cases, causing DNA damage and cellular senescence, and suggests they could be used for stillbirth risk screening.

The paper identifies circRNAs in Lotus japonicus under different nutrient and symbiotic conditions and suggests their role in regulating symbiosis through miRNA sponging.

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

The paper identifies circ5078 as a BMPR2-derived circular RNA that regulates endothelial proliferation and stress responses in PAH, with opposing effects to linear BMPR2 mRNA.

This study identifies human tRNA splicing elements that enable efficient intracellular auto-circularization of RNA, providing a framework for circRNA production.

The paper shows that TGF-β signaling, triggered by HIV-1 Vpr, increases ciTRAN expression through SMAD2/3 recruitment to the SMARCA5 promoter.

The paper identifies circular RNA isoforms of RNase P in bacteria, fungi, and human cells, showing improved stability and distinct protein interactions compared to linear forms.

This study identifies a 63-nucleotide element that promotes efficient circRNA translation, comparable to traditional IRESs, enhancing their therapeutic potential.

circAge compiles aging-associated circRNA data from 7 species and 21 tissues, identifying 413,378 unique circRNAs and their conservation, interactions, and coding potential.

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

This study demonstrates that ultrafiltration can purify circRNA with 86% purity and 50% yield, outperforming SE-HPLC.

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

This study shows circRNAs are highly stable in the aging fly brain and can indicate age and environmental experience.

The paper identifies circRNAs that regulate excitatory synaptogenesis in rat hippocampal neurons by modulating miR-128-3p activity.

The paper identifies essential circRNAs in human cancer cells and introduces FunCirc, a database of functional circRNAs across cancer cell lines and tissues.

The paper shows that loss of age-accumulated circ-crh-1 circRNAs reduces Aβ-induced toxicity in C. elegans, suggesting a protective role against Alzheimer's disease.

The paper identifies circNSD1 as a tumor suppressor in breast cancer that inhibits autophagy and oxidative stress tolerance.

This study identifies circPVT1 as a regulator of metabolic pathways in breast cancer by sponging miR-33a-5p, leading to increased c-MYC and GLS1 activity and promoting tumorigenesis.

This study identifies circDS-1, a circular RNA in Talaromyces marneffei, that promotes dimorphic transition and virulence, revealing a novel mechanism for fungal thermal adaptation.

This study identifies contaminants affecting circRNA functionality and develops a purification method to enhance its yield and reduce immune activation.

This study uses bibliometric analysis to explore circRNA cancer vaccines, identifying research trends and comparing them with mRNA vaccines.

The paper analyzes circRNA and RBP expression in GBM to identify their interactions and clinical relevance as stratification markers.

The paper examines circRNA expression in human dorsal root ganglia (hDRG) under opioid exposure and identifies differentially expressed circRNAs and their potential regulatory roles in pain pathways.

EasyCircR detects and reconstructs circRNA-miRNA-mRNA regulatory networks through post-transcriptional analysis and visualization.

This study shows circ-Cdr1as modulates macrophage phenotype and cardiac repair via the circ-Cdr1as-miR-7-Klf4 pathway, improving cardiac function post-myocardial infarction.

The paper introduces circtools 2.0, an enhanced software for circRNA detection and analysis, with new features for improved detection, probe design, conservation analysis, and support for Oxford Nanopore sequencing.

The paper identifies an siRNA effective against a modified circRNA, showing it can be targeted but with variable efficacy.

This study identifies ca-circSCN8A as a promoter of ferroptosis in HPASMCs under hypoxia by forming R-loops via LLPS of ca-circSCN8A/FUS/EP300, disrupting redox balance and contributing to pulmonary hypertension.

This paper introduces a method using poly(A) polymerase and oligo(dT) chromatography to purify engineered circular RNA, improving its purity and enabling enhanced protein expression in eukaryotic cells.