Circular RNAs in diseases

The human circular Tau 12->7 RNA is translated in mouse neurons and promotes tau aggregation

This study shows human circTau 12->7 RNA is translated in mouse neurons and causes tau aggregation, suggesting it may contribute to Alzheimer's disease.

Extensive and heterogeneous viral circular RNA production during Zika virus infection

This study identifies and validates viral circular RNAs produced during Zika virus infection in neural stem cells.

CircEPSTI1 regulates miR-942-5p-SERPINE1-AKT1 signaling axis to enhance dengue infection and is suppressed by Tiplaxtinin

This study identifies circEPSTI1 as a regulator of dengue infection through a miR-942-5p-SERPINE1-AKT1 signaling axis and shows that Tiplaxtinin suppresses this pathway to inhibit DENV replication.

The circ_0074371/miR-4738-3p/AMPK Signaling Axis Induces M1 Macrophage Polarization and Restricts Intracellular Survival of Mycobacterium tuberculosis

This study identifies circ_0074371 as a tuberculosis-associated circRNA that regulates AMPK activity and influences macrophage polarization via the miR-4738-3p/AMPK signaling axis, reducing Mtb intracellular survival.

Efficient permuted intron-exon RNA circularization system based on the LtrB group II Intron from Lactococcus lactis

This paper develops a system for efficient circRNA production using a permuted intron-exon configuration of the LtrB group II intron, showing high circularization efficiency and payload flexibility.

A false sense of circularity: hidden variability in RNase R enzymes confounds reliable circRNA validation

The paper shows that different RNase R enzymes from the same supplier can produce inconsistent results in circRNA validation, emphasizing the need for consistent verification with linear controls.

Chimeric archaeal BHB-human pre-tRNA scaffold HARBOR system enables versatile production of functional circular RNA modalities

The paper introduces the HARBOR system for producing functional circular RNAs with high efficiency and versatility in both cells and vivo.

A circRNA-derived IRES-like element enables programmable translational activation of the endogenous chaperone HSP90

The paper describes a synthetic circRNA-derived IRES-like element, SynFarsa, that enhances translation of an endogenous protein, HSP90, in trans by targeting its 3'UTR.

SON-mediated circular RNA suppression promotes PKR signaling and radiation resistance in glioblastoma

This study identifies SON as a suppressor of circRNA biogenesis in glioblastoma, linking circRNA depletion to PKR signaling and radiation resistance.

Verification of human nucleotide sequence reagents and cell line identities in original circRNA articles published in high impact factor journals

This study verifies nucleotide sequence reagents and cell line identities in circRNA papers and finds frequent errors in high-impact journals.

Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

This study shows that loss of TDP-43 function leads to increased cryptic circular RNAs in neurodegenerative diseases.

Regulation and Function of the HPV16 CircE7 RNA

This study investigates the regulation and function of HPV16 circE7 RNA, showing that m6A modification and IRES-like motifs are critical for its formation and translation, impacting viral replication and transformation.

Engineering circular RNA expression systems to minimize contaminating linear RNA byproducts

This paper develops a system to produce high-purity circular RNAs by minimizing linear RNA byproducts through optimized circularization and transcript termination strategies.

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia

The paper identifies a unique circRNA signature in congenital diaphragmatic hernia (CDH) lung development, showing miRNA sponging effects and pathway overlaps between rat and human CDH.

K9HeartCircDB: A circRNA Atlas of Tachypacing-Induced Canine Dilated Cardiomyopathy

The paper introduces K9HeartCircDB, a database of circRNAs in canine heart tissue under tachypacing-induced HF, providing tools for circRNA exploration and validation.

Ouro-seq: Improved Recovery of Full-Length circRNAs from Samples with Limited RNA Content

Ouro-seq improves full-length circRNA recovery from low-RNA samples, revealing distinct circRNA types and functions in clinical contexts.

Noncanonical Circular RNAs and Potential Functions

This study identifies and validates noncanonical circRNAs in lung cancer, showing they are abundant, functional, and clinically relevant.

Characterization of Chromatin-Associated Circular RNAs (cacRNAs)

The paper identifies hundreds of chromatin-associated circular RNAs (cacRNAs) in human cells and shows their interaction with chromatin and RNA-binding proteins.

CircDiscoverer: A multispecies comprehensive resource for circRNA-protein interactions and RNA modification landscapes

CircDiscoverer provides a resource for exploring circRNA-protein interactions and RNA modifications across multiple species.

MycoCirc: A Pan-Fungal Multi-Modal Pretrained Model for Fungal circRNA Prediction from Genome Sequence

The paper introduces mycoCirc, a pan-fungal model for circRNA prediction from genome sequences, achieving better performance than existing methods across multiple fungal groups.

CircZBTB46, a promising therapeutic target in crizotinib resistant ALK-positive T lymphomas

The paper identifies circZBTB46 as a driver of crizotinib resistance in ALK-positive lymphomas and shows its targeting restores drug sensitivity.

SATB2 and circ3915 RNA chromatin dysregulation drive KRAS-like oncogenic transformation

This study shows that SATB2 and circ3915 RNA chromatin dysregulation can drive KRAS-like oncogenic transformation in lung epithelial cells without driver mutations.

Temporal and Regional Circular RNA profiling in a Tauopathy Mouse Model: Implications for Tau Pathology and Neurodegeneration

The paper profiles circRNA in a tauopathy mouse model across age and brain regions, identifying circRNA-miRNA regulatory networks linked to tau pathology and neurodegeneration.

circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis

This study identifies circPMS1 as a pro-metastatic circRNA in melanoma that promotes cytoskeletal remodeling and metastasis by scaffolding LIM proteins.

Circular RNA vaccine performance is determined by RNA quality and epitranscriptomic tuning rather than innate activation

This study shows that circRNA vaccine performance depends on RNA quality and epitranscriptomic modifications rather than innate immune activation.

SRPK3 regulates back-splicing of pre-MYOCD through Phosphorylating SRSF10 to modulate cardiac hypertrophy

This study identifies SRPK3 as a regulator of cardiac hypertrophy through its effect on circ-MYOCD biogenesis via phosphorylation of SRSF10.

M6A-modified circEZH2 Protects Endothelial Cells from Senescence and Suppresses Atherosclerosis by Stabilizing ZNF326

This study identifies circEZH2 as an m6A-modified circRNA that suppresses endothelial cell senescence and atherosclerosis by stabilizing ZNF326.

Circular RNA-associated QTLs show stronger association with splicing-QTLs than with expression-QTLs

The paper compares circQTLs with splicing and expression QTLs, finding stronger genomic overlap with splicing-QTLs and distinct genomic distribution patterns.

Revealing the convergence of disease- and risk-associated circular RNAs in schizophrenia and bipolar disorder

The paper identifies disease-specific circular RNAs in schizophrenia and bipolar disorder, linking them to genetic risk, synaptic biology, and brain structure through transcriptomic and imaging analyses.

HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization

This study identifies hnRNP C as a repressor of circRNA biogenesis in Group 3 medulloblastoma by binding Alu elements and preventing pre-mRNA circularization.