Nicotinic Acetylcholine Receptors Study

The paper identifies a mutation in the pre-β5 strand of GLIC that changes crotonate from a negative to positive modulator, suggesting its role in coupling ligand binding to pore gating.

The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.

This study shows that xanomeline restores age-related nicotinic signaling deficits in mouse prefrontal cortex by enhancing muscarinic receptor pathways and nicotinic receptor availability.

The paper shows cholinergic boutons contact VIP neurons in the inferior colliculus, influencing their synaptic computations.

The paper investigates how a deletion in RIC3 affects splicing and nAChR regulation in human astrocytes under ER stress, identifying potential therapeutic targets.

The paper identifies new inhibitory acetylcholine-gated ion channels in C. elegans with diverse ligand binding properties and reveals neurons expressing both excitatory and inhibitory channels.

This study identifies CASK and FARP as scaffolding proteins that localize post-synaptic ACh receptors, enhancing cholinergic transmission in C. elegans.

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

This study evaluates an image-derived input function for PET ligand kinetic modeling in mice, showing improved quantification compared to reference tissue methods for nicotinic receptor-binding tracers.

The paper identifies the conserved role of α2δ subunits of calcium channels in nicotine-motivated behavior across species using C. elegans and human GWAS data.

The paper reconstitutes the N-AChR from Brugia malayi in Xenopus oocytes, showing that its response is progressively reduced compared to related species and requires accessory proteins.

This study shows that tonic activation of 4β2 nicotinic acetylcholine receptors on GABAergic interneurons primes feedforward inhibition, shaping striatal output timing and synaptic plasticity.

This study identifies Drosophila nAChR subunits interacting with insecticidal toxins using CRISPR/Cas9 and pull-down assays, providing insights for insecticide design.

The paper identifies two RIC-3 binding sites in 5-HT3A subunits, with a duplicated motif, and shows their role in modulating surface expression.

This study identifies 4R-Tobacco-Cembranoid as a positive allosteric modulator of 7nAChRs that reduces thermal hypersensitivity and inflammation in mice, with sex-specific effects.

This study shows that nicotinic signaling is necessary for motor learning but not for rehabilitation of previously learned movements after spinal cord injury.

The paper identifies Chrna5-expressing super-responder subplate neurons using transgenic mice and single-cell transcriptomics, revealing unique lynx prototoxin gene expression and potential therapeutic targets for attention disorders.

The paper measures channel opening durations in nicotinic acetylcholine receptors (nAChRs) by recording single-molecule currents and finds that agonist binding at specific sites determines opening durations and burst patterns.

This study identifies distinct nAChR subunit compositions responsible for the toxicity of various nicotinic modulation insecticides in Drosophila melanogaster.

NAChRDB provides a web resource with curated residue-level functional annotations and 3D visualization for neuromuscular nAChRs to aid in understanding their allosteric mechanisms.

This paper develops a photochromic ligand, DitIMI, that modulates invertebrate nAChR activity and behavior in mosquitoes and cockroaches, and serves as a tool for high-throughput screening.

This study shows that 3β4* nAChRs strongly excite VIP neurons in the mouse inferior colliculus, influencing auditory processing through prolonged excitability.

The paper identifies molleamine C as a partial antagonist of nicotinic acetylcholine receptors with potential for neuroactive drug development.

This study identifies SDN-1 as a critical organizer of cholinergic synapses in C. elegans by clustering AChRs and interacting with synaptic components.

The paper identifies genes affecting levamisole sensitivity in C. elegans by RNAi screening, revealing roles in muscle function and metabolic processes.

The paper shows that cholinergic signaling at the body wall neuromuscular junction in C. elegans inhibits feeding by coupling with locomotion control.

The paper investigates the reduced efficacy of choline as an agonist at mammalian 910 nicotinic acetylcholine receptors, linking this change to evolutionary adaptations in the 10 subunit.

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

This study identifies Vangl2 as a regulator of MuSK signaling in neuromuscular synapse formation, showing its role in AChR accumulation and NMJ stability.