Lipid metabolism and biosynthesis

This study identifies plaat1l1 as a key enzyme for feeding-induced NAPE biosynthesis in zebrafish, showing its role in energy balance regulation and obesity prevention.

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

The paper investigates the role of VPS28 in triglyceride synthesis through modulation in bovine cells and a mouse model, showing its regulation via the ubiquitination pathway.

This study shows that alka(e)nes are essential for maintaining membrane lipid homeostasis and photosynthetic resilience to high light in cyanobacteria.

This paper introduces FABCON, a tool for detecting lipid droplet-organelle contact sites in living cells, showing their dynamic behavior under different metabolic conditions.

This study identifies and functionally characterizes Elovl proteins in Platynereis dumerilii, revealing their role in LC-PUFA biosynthesis and a unique KH domain in one Elovl4 gene.

This study shows that knocking out delta-5 elongase in a marine diatom reduces DHA and TAG synthesis and increases heat sensitivity.

Biotic and heat stress strongly alter the lipidome and proteome of Arabidopsis leaves, including lipid droplet proteome composition.

This study identifies AtVPS13M1 as a lipid transporter in Arabidopsis thaliana that affects phospholipid degradation during phosphate starvation and localizes to mitochondria.

The paper identifies a novel class of cardiolipins in a sulfate-reducing bacterium using UHPLC-HRMSn, revealing structural and biosynthetic features distinct from archaeal tetraether CDLs.

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.

This study identifies lipid imbalances in TANGO2-deficient human cells and shows vitamin B5 supplementation rescues these imbalances, suggesting a role for TANGO2 in lipid metabolism.

This study models 3D structures of fatty acid biosynthesis enzymes in Scenedesmus quadricauda and compares them to other species, revealing conserved domains and unique features linked to high lipid accumulation.

This paper identifies Bez, a scavenger receptor in Drosophila, as essential for lipid transfer from fat body to oocytes, contributing to reproductive success.

This study investigates the role of LSD1 in lipid metabolism of Hermetia illucens, finding it promotes larval growth without affecting fat content or development.

This study identifies and characterizes a fatty acid synthase gene in Hermetia illucens, elucidating the molecular origin of lauric acid production through in vitro experiments in yeast.

The paper identifies switch mutations in ATGL that selectively disrupt interactions with specific regulatory proteins, linking these mutations to altered lipolysis activity and disease relevance.

The paper investigates how dietary lipid manipulations affect the Drosophila eye proteome and identifies lipid-responsive proteins involved in muscle function and stress responses.

The paper uses chemoproteomic profiling to identify active serine hydrolases in Phaeodactylum tricornutum, revealing lipases as key players in lipid remobilization during nitrogen replenishment.

LipidSIM infers lipid biosynthesis perturbations from lipidomics data using a low-parameter Markov model, demonstrating its utility in studying disease-related lipidome changes.

This study identifies how dietary vitamin B12 influences phosphatidylcholine metabolism in C. elegans, affecting fat content through pathways involving SAM, PC, and regulatory proteins.

This paper identifies RfaA as a regulator of fatty acid synthesis in Bacillus subtilis that targets AccC for degradation in the absence of glutamate, preventing fatty acid toxicity.

This paper introduces ultralow background membrane editors for PA that use light to control PLD activity, revealing subcellular differences in PA metabolism and signaling.

The paper investigates the roles of GPATs and GNPAT in lipid synthesis, showing their impact on ether lipid levels, acyl chain regulation, and cell survival.

This study identifies spartin as a lipid transfer protein essential for lipid droplet turnover via lipophagy, revealing a new lipid transport module in its senescence domain.

This study uses simulations to show lipid droplet (LD) formation and budding are governed by ER and LD tensions, with budding being energetically neutral and tension-independent.

This study shows DHRS1 localizes to lipid droplets in HeLa cells and alters their morphology, with ERLIN1 potentially regulating DHRS1's effect on lipid droplet size and triacylglycerol levels.

This study identifies genetic suppressors of a BSCL2 pathogenic variant in C. elegans, revealing potential interactors and pathways involved in seipin function.

This study identifies a novel adp loss-of-function mutant in Drosophila and shows it does not affect brain growth despite changes in lipid metabolism.

The paper identifies Mover/TPRG1L as a lipid droplet protein in astrocytes and shows its role in lipid droplet accumulation and targeting.