Lipid metabolism and biosynthesis

Zea Lip: An atlas of glycerolipid profiles across leaf development in maize

UHPLC-MS/MS lipidomics of maize leaves (149 species, three genotypes, four growth stages, three leaf zones) shows genotype and leaf number explain most lipid variation.

Sfh3 is a sterol-modulated PI/PI4P transfer protein that confers azole resistance in yeast by specifically mediating lanosterol/PI exchange

A thioester-thiol exchange reaction in Salmonella Invasion acyl carrier protein transfers the 4PP-bound acyl chain to a distal cysteine

This paper identifies a thioester-thiol exchange reaction in IacP that transfers the 4PP-bound acyl chain to a distal cysteine, revealing a mechanism for SipB acylation in Salmonella.

Seipin and perilipin 3 promote distinct early steps of nascent lipid droplet biogenesis

This study identifies seipin and perilipin 3 as distinct regulators of early lipid droplet biogenesis by promoting nucleation and stabilizing nascent droplets, respectively.

Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets

This study identifies OPA1's role in fatty acid release from lipid droplets and links its function to human metabolism.

Triacylglycerol fatty acid composition modulates ATGL regioselectivity and diacylglycerol output

This study shows that ATGL's regioselectivity in cleaving triacylglycerol depends on fatty acid chain length and composition, leading to specific diacylglycerol regioisomers.

Fatty acid metabolism and dietary lipid composition shape B-cell responses

This study shows that fatty acid metabolism and dietary lipid composition influence B-cell activation, proliferation, and germinal-center responses through distinct metabolic and biophysical mechanisms.

DTH1-dependent remodeling of the lipid and protein environment of lipid droplets during nutrient recovery in Chlamydomonas

This study investigates the role of DTH1 in remodeling lipid and protein environments of lipid droplets during nutrient recovery in Chlamydomonas, revealing its impact on lipid degradation and organelle communication.

Acetylated PLIN2 coordinates the innate immune system and oxylipin synthesis on lipid droplets to propagate inflammation

This study identifies acetylated PLIN2 as a critical mediator of inflammation by facilitating oxylipin synthesis on lipid droplets through interactions with inflammatory proteins.

The Sorghum Lipid Database (SoLD): population-scale lipidomics linking environmental and genetic variation in the Sorghum Association Panel

SoLD, a leaf lipidomics resource (244 species) for the Sorghum Association Panel across two field trials, reveals low-input sulfoquinovosyldiacylglycerol depletion, triacylglycerol enrichment, and environment-specific GWAS loci.

The functional neuronal lipotype is specified by activity and PS synthesis using dietary and lysosomal inputs

The paper identifies n-3 phosphatidylserines as a conserved neuronal lipotype dependent on dietary and lysosomal inputs, showing its role in synaptic function and circuit behavior.

A FIT2-BLTP1 module sustains lipid droplet phosphatidic acid and restrains overgrowth

This study identifies BLTP1 as a key protein that maintains phosphatidic acid in lipid droplets, preventing overgrowth and ensuring proper LD formation.

Artificial endoplasmic reticulum-lipid droplet tethers facilitate lipid incorporation into lipid droplets

This study uses a dimerization-dependent fluorescent protein system to induce ER-LD membrane contact sites, showing that artificial tethering increases LD size by facilitating lipid incorporation from the ER.

Mechanism of substrate recognition and catalysis in a mammalian phosphatidylserine synthase 2

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

A Novel and Evolutionarily Conserved Metabolic Axis for Efficient Hepatic Lipid Catabolism Governed by Mfn2-Hsl-Mediated Mitochondria-Lipid Droplet Coupling

The paper identifies a novel Mfn2-Hsl-mediated mitochondria-lipid droplet coupling mechanism that enhances hepatic lipid catabolism and is evolutionarily conserved across species.

Protein hunger-driven nitrogen flow from phospholipids to amino acids inDrosophila

The paper shows that Drosophila reallocates nitrogen from phospholipids to amino acids under protein deprivation, mediated by the microbiome and ETNPPL pathway.

Bioengineered algal lipids enriched in structured medium- and long-chain triacylglycerols, linoleate, and sn-2 palmitate for human milk fat substitutes

The paper describes engineered algal lipids that mimic the fatty acid profile and regioisomeric structure of human milk fat for infant formula.

Multiomics Reveals IGF-1 c.258A > G Reduces Triacylglycerol Containing Medium-Chain Fatty Acid in Milk

The paper identifies a synonymous mutation in IGF-1 that reduces milk triacylglycerol containing medium-chain fatty acids in mice and pigs, revealing its molecular mechanism.

Hexose-6-phosphate dehydrogenase deficiency disrupts hepatic fatty acid homeostasis and induces triglyceride accumulation

This study shows that H6PD deficiency in mice leads to increased hepatic triglycerides and lipid accumulation, linking NADPH availability to fatty acid homeostasis.

A Synthetic Archaeal Lipid Analog Enables Quantification of Substrate, Products, and Intermediates in the Tetraether Synthase Reaction

The paper introduces a synthetic lipid analog to quantify reaction intermediates and products in the Tetraether Synthase reaction, revealing a new GDGT-to-mAG ratio.

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

The paper shows that BrtB in Synechocystis captures free fatty acids at the cell envelope without activation, generating B-FAs and suggesting a new pathway for FFA incorporation.

Cryo-EM structures reveal the mechanism of phosphatidylserine remodeling by membrane-bound glycerophospholipid O-acyltransferase 1

The paper determines how MBOAT1 remodels phosphatidylserine by solving its cryo-EM structures and combining them with lipidomics and simulations.

Activation and inactivation pathways of a p53-like transcription factor govern lipid homeostasis in yeast

The paper identifies activation and inactivation pathways of Mga2, a p53-like transcription factor in yeast, showing its role in lipid homeostasis through regulation of Ole1 expression.

Lipogenic gene expression and substrate sensitivity in the bovine mammary gland shape milk fat composition

The paper investigates how bovine mammary epithelial cells (MEC) utilize acetate for de novo fatty acid synthesis, preferentially producing medium chain fatty acids through ACSS1 and DGAT upregulation.

Chromosome-scale genome of the woody oilseed crop sacha inchi elucidates the molecular basis of alpha-linolenic acid biosynthesis and triacylglycerol accumulation in seeds

This study presents a chromosome-scale genome of sacha inchi, revealing mechanisms of ALA biosynthesis and TAG accumulation through transcriptome analysis and gene expression patterns.

Avocado-derived compounds alter lipid homeostasis and lipid droplets profile in Caenorhabditis elegans

This study shows avocado-derived compounds alter lipid homeostasis and lipid droplet profiles in C. elegans by disrupting mitochondrial function and lipid metabolism.

Comparison of the 4-helix bundle domains of perilipin 3 and perilipin 4 identifies features that contribute to lipid droplet binding

This study compares the 4-helix bundle domains of perilipin 3 and perilipin 4 to identify structural features that influence their binding to lipid droplets.

Endogenous lipid droplets exhibit profound proteomic and lipidomic differences across neural stem cell states

The paper identifies state-dependent proteomic and lipidomic differences in lipid droplets of neural stem/progenitor cells and shows CIDEB's role in maintaining quiescence.

APOE genotypes differentially remodel the astrocytic lipiddroplet-associated proteome to shape lipid droplet dynamics

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

LipoGrid: A High-Throughput Multi-omics Perturbation Screen Dissects the Genetic Architecture of Lipid Metabolism

LipoGrid quantifies lipidomic and transcriptomic changes across 143 gene knockouts, revealing gene-lipid relationships and compensatory feedback mechanisms.