武士 原山

This study shows that deleting ferritin heavy chain in medulloblastoma cells limits tumor growth by promoting iron-dependent stress and sensitizing cells to iron toxicity.

MSLipidMapper provides a pathway-centered lipidomics analysis tool that integrates lipid structure, subclass annotations, and multi-omics data for structured exploration.

This study shows that ether lipid remodeling during neuronal differentiation prevents ferroptosis by balancing pro- and anti-ferroptotic effects through vinyl ether bonds.

This paper develops a method to selectively manipulate and functionalize specific lipid classes in living cells using synthetic lipid analogs and bifunctional lipids.

This study shows that seipin regulates CAV1 trafficking and organelle interactions by controlling lipid metabolism and membrane order, impacting cellular homeostasis and metabolic disorders.

The paper introduces ZT Scan DIA, a metabolomics method improving annotation rates and isomer quantification in complex mixtures, with results validated in human plasma and mouse liver tissues.

This study identifies VLC fatty acids as mediators of 1-deoxySL toxicity through mitochondrial dysfunction and BAX-dependent apoptosis.

The paper introduces MS-DIAL 5, a tool for analyzing multimodal mass spectrometry data to elucidate lipid structures and localization using structural annotations.

The paper investigates the roles of GPATs and GNPAT in lipid synthesis, showing their impact on ether lipid levels, acyl chain regulation, and cell survival.

This paper introduces GENF, a gene disruption strategy that avoids clone isolation, enabling reliable lipidomics analysis and revealing lipid co-regulatory networks.