Barrier Structure and Function Studies

The paper uses mouse retinal models to characterize pericyte diversity and demonstrate targeted control of capillary blood flow through optogenetic manipulation.

The paper develops and validates a quantitative method using sodium fluorescein to assess BBB and BSCB integrity in neurodegenerative disease models, showing increased permeability in specific disease models.

This study investigates the role of NHE1 in BBB integrity during CSD events and its impact on drug uptake, finding that NHE1 disruption affects BBB function and sumatriptan penetration.

This study shows that astrocytes from 3xTG-AD mice impair BBB integrity in vitro through paracrine mechanisms, as evidenced by reduced tight junction protein expression and TEER.

This study identifies a TRA2A/LINC00662/ELK4 axis that regulates BBB permeability in Alzheimer's disease by affecting ELK4 mRNA stability.

This study investigates how acute systemic inflammation affects neurovascular unit function and cerebrovascular dynamics in rats, showing altered haemodynamics and NVU pathology.

This study shows that reduced TNAP enzyme activity in cerebral microvessels during late sepsis is linked to neuroinflammation and behavioral changes like anti-nociception.

This study shows that apoM-bound S1P regulates BBB permeability and transcytosis, with S1PR1 agonists able to restore permeability in apoM-deficient mice.

The paper demonstrates that Plvap regulates the rate of blood-borne protein passage through fenestrated endothelia in the hypophysis using zebrafish models.

This study shows liposomes can selectively enter the brain after stroke through two distinct BBB disruption phases, offering new therapeutic opportunities for targeted drug delivery.

This study shows glucose exposure harms the neurovascular unit and behavior in zebrafish, but sodium nitroprusside reverses these effects.

The paper studies zebrafish blood-brain barrier development, finding that suppression of transcytosis is critical for BBB formation and that Mfsd2a plays a conserved role in this process.

This study shows that amyloid β oligomers constrict human capillaries via pericyte signaling, reducing blood flow and contributing to Alzheimer’s disease pathology.

The paper describes the discovery of transient NO-containing spherical structures in zebrafish cerebral endothelial cells during development, showing their dependence on Notch signaling.

The paper generates human pluripotent stem cell-derived brain pericyte-like cells that induce blood-brain barrier properties in endothelial cells and form an isogenic NVU model.

This study uses single-cell RNA sequencing to show that brain endothelial cells respond to circulatory cues of aging, with aged plasma inducing aging transcriptomes and young plasma reversing them.

The paper shows that the Drosophila blood-brain barrier has a circadian permeability rhythm driven by a clock in perineurial glia, with nighttime increased permeability enhancing drug efficacy.

This paper introduces a transgenic zebrafish model expressing claudin 5a to study the development and function of the blood-brain barrier and choroid plexus barrier in vivo.

The paper identifies two transitional mural cell types in adult mouse cortex with distinct -smooth muscle actin levels and morphological features.