Barrier Structure and Function Studies

This study shows simvastatin preserves endothelial barrier function by modulating RhoB localization and activation through mevalonate-dependent mechanisms during TNF stimulation.

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

The paper shows that visual experience drives metabolic changes in endothelial cells by switching lactate and glucose transporters, essential for vascular and BBB maturation.

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

This study investigates whether astrocyte-derived Wnt7a deficiency contributes to BMEC dysfunction during Plasmodium infection, finding no protective effect of Wnt7a overexpression on cerebral malaria outcomes.

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

This study shows that breast cancer-derived PDGFB remodels the CNS vascular niche, promoting brain, spinal, and leptomeningeal metastasis through multiple mechanisms.

This study identifies CD36-associated vascular changes in Alzheimer's disease and shows CD36's role in regulating endothelial metabolic and immune programs, with potential for targeted therapies.

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

This study shows that Cyclin E/CDK2 deficiency enhances intestinal barrier integrity and tight junction expression in mice, contrary to initial hypotheses.

This study shows that NE52-QQ57 reduces post-ischemia protein phosphorylation and crosses the blood-brain barrier in mice.

This study identifies ligand-specific endothelial Notch signaling as a mechanism coordinating brain pericyte specification and expansion in zebrafish.

This study examines Ogerin's pharmacokinetics in mice and its effect on post-ischemia signaling, finding it most effective in acute hours after injection.

This study compares postnatal maturation of the gliovascular unit in male and female mice, revealing sex-specific differences in angiogenesis, cell composition, and transcriptomic trajectories regulated by oestrogenic signalling.

The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.

This study maps the biophysical interaction network of ZO-1 with tight junction transmembrane proteins, revealing how they couple intracellular and extracellular signaling through binding mechanisms and phase separation.

This study shows that CD2AP regulates endothelial barrier function and immune cell transmigration, linking it to Alzheimer's disease.

This study links LDL-C to cerebral pericyte dysfunction in acute ischemic stroke through clinical and experimental evidence, showing oxidative stress and type-I interferon signaling changes.

This study reviews and analyzes the association between APOE genotype and fluid biomarkers of blood-brain barrier integrity, finding significant associations for APOE ε2 but not ε4.

The paper examines the organization of axons around cortical vasculature in mice, finding that axons form micro-tracts around capillaries, which may facilitate neurovascular coupling.

STED imaging quantifies luminal versus abluminal localization of blood-brain barrier proteins in vivo; tyrosine motifs drive abluminal sorting of OAT3 and MHC I, and CD31 shifts day to night.

The paper designs a high-affinity CLDN5 peptide binder, ST9, that induces reversible, size-controlled BBB openings without altering CLDN5 expression or proteomic profile.

This paper develops a lab-on-a-chip system integrating a human BBB model with neural organoids to study BBB function and nanoparticle transport, showing BBB integrity and nanoparticle entry into neural tissue.

This study investigates how reperfusion affects neurovascular injury after ischemic stroke, finding that while it reduces acute damage, it leads to chronic vascular dysfunction.

The paper shows low testosterone increases anxiety by altering astrocytic mitochondrial structure and function at the nucleus accumbens blood-brain barrier in rats.

This study shows that Wnt/beta-catenin signaling modulates VEGF receptor levels in CNS endothelial cells, thereby regulating VEGF signaling.

This study identifies small molecules that temporarily open the blood-brain barrier in zebrafish and mice, with reversible effects and potential for drug delivery.

The paper investigates how intestinal inflammation affects the blood-brain barrier (BBB) and identifies transthyretin (TTR) as a key factor in BBB recovery, with reduced TTR expression linked to Alzheimer's disease.

The paper introduces a computational framework to predict cerebral pericyte contractility under various experimental and physiological conditions, validated across multiple interventions.