dental development and anomalies

This study shows that enamel hypomineralization alters dental pulp and trigeminal nerve structure, transcriptome, and injury response without direct pulp exposure.

This study examines oral tooth development and evolution in threespine sticklebacks, finding variable spatial sequences, sexual dimorphism in late juvenile stages, and increased tooth numbers in freshwater fish.

The paper examines molecular conservation patterns during molar development in mice and hamsters, finding that conservation varies with developmental stage and is influenced by both intrinsic and extrinsic evolutionary pressures.

This paper uses neonatal brain MRI to quantify dental maturity and links it to prenatal factors and tooth eruption timing.

This study identifies Foxp4+ mandibular skeletal stem cells (mdSSCs) that drive bone/tooth development and regeneration, showing their therapeutic potential in regenerating mandibular structures.

This study identifies structural defects in radicular and periodontal tissues in Hyp mice, linking them to refractory dental complications in X-linked hypophosphatemia.

This study identifies an alternative epithelial patterning mechanism for vertebrate tooth complexity in squamates, showing that cusp formation does not rely on enamel knots but on a broad signaling field.

The paper uses a multimodal framework to reveal unique mineralization defects in a TBCK syndrome mouse model, identifying early-stage changes in enamel and dentin composition.

This study shows TENT5A polyadenylates enamel matrix protein mRNAs, enhancing their stability and translation, which is essential for proper enamel mineralization.

The paper identifies genes and regulatory networks involved in shark tooth regeneration using RNAseq, highlighting the role of mycn in dental stem cell proliferation.

This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.

The paper demonstrates that a designed soluble Notch agonist can drive iAM maturation without odontoblast contact, revealing DLX3's role in ameloblast-specific Enamelin and MMP20 expression.

This study shows p63 uses a skin keratinization mechanism for enamel organ development, revealing a shared pathway in tissue specialization.

The paper identifies an inverse hourglass pattern of conservation in rodent molar development, showing greater conservation at early and late stages than intermediate ones.

This study shows that Pax9 mutation in zebrafish causes midfacial retrusion and loss of facial appendages, but not pharyngeal teeth, suggesting Pax9's role in mesenchymal condensation for non-tooth structures.

This study examines mechanical and chemical properties of developing enamel, dentin, and bone in mouse mandibles using multi-modal techniques and finds distinct patterns of changes driven by mineral composition.

The paper identifies key transcription factors in Sox2+ dental epithelial stem cells from embryonic and postnatal stages using single-cell RNA-seq and ATAC-seq.

This study shows that SLC26A2-mediated sulfate metabolism is essential for tooth development, as its deficiency leads to craniofacial abnormalities and tooth hypoplasia in mice.

The paper identifies transcription factors and regulatory networks involved in dental lamina specification during tooth initiation using single-cell Multiome-seq and RNA-seq.

This study investigates tooth replacement patterns in geckos after tooth removal, finding evidence of local signaling and proposing a new Phase Inhibition Model.

This study shows that Notch signaling, specifically through Jagged1, influences tooth-crown shape variations in mice, mirroring evolutionary changes observed in Muridae.

This study shows that Med1 deletion in dental epithelia causes a shift from enamel to hair lineage through changes in enhancer dynamics and transcriptional programs.

The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.

This study identifies USAG-1 as a drug target for teeth regeneration and proposes a natural lead molecule to induce regeneration while addressing side effects.

This study investigates the role of Foxi3 in early tooth development, showing its necessity in suppressing signaling center fate and regulating epithelial proliferation and shape.

The paper identifies candidate dental disease genes by integrating chromatin state, bulk gene coexpression, and single-cell RNA sequencing data from developing mouse teeth.

The paper identifies a minimal tooth enhancer that regulates dlx2b expression in zebrafish tooth development and shows how its disruption affects gene expression patterns.

This study identifies MAST4's role in regulating DLX3 and stem cell maintenance in mouse incisor development, leading to Amelogenesis Imperfecta.

This study identifies an evolutionarily conserved odontode gene regulatory network in suckermouth armored catfish that underlies dermal denticles development.

The paper identifies a gene signature specific to the enamel knot in developing mouse molars using scRNA-seq data and validates novel marker genes.