dental development and anomalies

The paper studies tooth regeneration in cichlid fishes, identifying accelerated replacement and cellular interactions involved in the process.

This study uses whole exome sequencing and multi-omics integration to identify genetic variants associated with congenital tooth agenesis, revealing potential biomarkers and therapeutic targets.

The paper uses quantitative proteomics to show that a low-protein diet during development alters protein expression in mouse molars without affecting size or skull length.

This study shows that overexpressing Ectodysplasin (Eda) in sticklebacks and zebrafish can induce tooth formation in multiple oropharyngeal and cranial domains, revealing dynamic spatial and temporal competency for ectopic tooth initiation.

This study investigates the development and evolutionary origin of extraoral teeth in chimaeras, finding they develop similarly to oral teeth and are homologous rather than modified denticles.

This study investigates tooth development in frogs, finding that the upper jaw retains a conserved tooth gene network, while the mandible lacks evidence of tooth development, suggesting evolutionary constraints on re-evolving lost mandibular teeth.

The paper identifies Mx1-labeled pulp progenitor cells as the main contributors to postnatal odontoblasts and pulp cells in murine molars through single-cell analysis and injury studies.

This study investigates the role of KMT2D in amelogenesis using a conditional knockout mouse model, revealing its critical role in enamel development and identifying direct target genes involved in ameloblast differentiation.

The paper examines how bear dentition development deviates from the Inhibitory Cascade model, showing initial conservation but later divergence in molar size proportions.

This study identifies dental genes under positive selection in voles with different molar root structures, linking genetic changes to tooth growth patterns.

The paper investigates the role of Wnt and BMP signaling in tooth regeneration in fish, finding that Wnt promotes and BMP inhibits regeneration, similar to hair regeneration.

The paper investigates how mammalian molar teeth scale during development and evolution, finding that the IGF pathway regulates both growth and cusp patterning to achieve size differences.

This study investigates the role of XEDAR in mammary gland development using a mouse knockout model, showing its specific role in post-pubertal growth and branching.

This study examines the development of shark denticles, finding they share a gene expression signature with teeth but lack a stem cell niche for regeneration.

The paper identifies a novel PAX9 mutation causing non-syndromic tooth agenesis through in vitro and computational analysis.

This study maps the transcriptional landscape of developing mouse mandibular epithelium to identify key transcription factors and gene regulatory networks involved in oral epithelial patterning and organ specification.

The paper shows that an enamel knot-like signalling centre is conserved in sharks, supporting its homology across vertebrates despite differences in signalling.

This study shows that FGF8 signaling in the dental mesenchyme slows tooth development by promoting cell proliferation and blocking apoptosis.

The paper compares tooth regeneration systems in zebrafish and stickleback to show they use a conserved set of genes during regeneration.

The paper identifies new pathogenic variants in the MMP20 gene associated with autosomal recessive amelogenesis imperfecta and explores their genetic origins across different populations.

This study shows that Tfap2a and Tfap2b have tissue-specific roles in tooth development, with epithelial expression critical for incisor morphology and mesenchymal expression having little effect.

The paper identifies developmental keystone genes in mouse and rat tooth development by analyzing phenotypic severity and gene expression patterns, revealing conserved system-level dynamics.

The paper models Edar expression dynamics to reveal hidden patterning processes in tooth signaling centers, showing a two-step activation and erasure mechanism.

The paper identifies a de novo EDA mutation causing X-linked hypohidrotic ectodermal dysplasia in shorthaired standard Dachshunds through whole-genome sequencing and family analysis.

The paper identifies novel genes for tooth development by associating CRC risk variants with tooth agenesis and showing gene expression in developing teeth.

This study shows that zebrafish lacking sp7 can replace teeth without attachment bone, but with poor differentiation and abnormal tooth orientation.

This study shows BMP signaling is required for MSC lineage commitment and identifies downstream transcription factors that determine cellular identities in dental mesenchyme.