High Altitude and Hypoxia

Reduced baseline male fertility and increased sensitivity to hypoxic stress in high-elevation deer mice

This study finds that high-elevation deer mice have reduced baseline fertility and greater sensitivity to hypoxia compared to low-elevation mice, with gene expression changes suggesting adaptive testicular regression.

Plasma erythropoietin responses across repeated exposure to normobaric hypoxia in healthy older adults

This study shows that plasma erythropoietin (EPO) responses remain consistent across repeated normobaric hypoxia exposures in healthy older adults, indicating sustained activation of hypoxia-responsive pathways.

Comparative and population genomics analyses of eared pheasants inhabiting highly varying altitudes

The paper compares genome sequences and genetic variations of three eared pheasant species at different altitudes to identify adaptation mechanisms.

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure

This study investigates immune and metabolic changes in individuals adapting to high altitude using single-cell transcriptomics and metabolomics, revealing immune activation and metabolic shifts linked to adaptation.

A pleiotropic EPAS1 enhancer mediating Tibetan adaptation to hypoxia is active in adipocytes

The paper investigates the role of the EPAS1 enhancer ENH5 in adipocytes, showing its conditional effects on thermogenesis and adipocyte differentiation under hypoxia and thermogenic stimulation.

Glucocorticoid Programming of Erythrocyte Hypoxic Memory Enables Rapid High-Altitude Acclimatization

This study identifies glucocorticoids as mediators of hypoxic memory in erythrocytes that enhance oxygen delivery and reduce AMS severity through metabolic reprogramming.

Normobaric hypoxia alters the transcriptional response of healthy human skeletal muscles to a single session of high-intensity interval exercise

This study examines how normobaric hypoxia affects gene expression in skeletal muscle after high-intensity interval exercise, finding more differentially expressed genes in hypoxia at 24 h post-exercise.

Hemodynamic phenotypes linked to high-altitude subclinical organ damage

This study identifies three distinct hemodynamic phenotypes in high-altitude dwellers and links them to subclinical organ damage.

Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

Elevational variation in heart mass and suppression of hypoxia-induced right ventricle hypertrophy in Andean leaf-eared mice (Phyllotis)

The paper examines elevational variation in heart mass and RV hypertrophy in Andean leaf-eared mice, finding that suppression of RV hypertrophy is linked to differential gene expression in high-altitude populations.

Association between EPAS1 and ATP6V1E2 Polymorphisms and Susceptibility to High Altitude Polycythemia in Chinese Tibetan Population

This study identifies genetic polymorphisms in EPAS1 and ATP6V1E2 associated with susceptibility to high altitude polycythemia in Tibetan populations.

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptation

The paper identifies novel structural variants and archaic introgressions in Tibetan genomes linked to high-altitude adaptation.

Integrated multiomics reveals inflammation-driven excessive erythrocytosis in subjects with Monge's disease

This study uses multiomics analysis to show that inflammation-driven NFκB activation under hypoxia causes excessive erythrocytosis in Monge's disease.

Training and match running distances and perceived exertion at sea-level and altitude in elite North American soccer: A natural longitudinal cross-over case series.

This study compares training and match running distances and perceived exertion at sea-level and altitude in elite soccer players, finding increased breathlessness relative to leg exertion at altitude.

Effect of high-altitude exposure on skeletal muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents

This study examines how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, and respiratory capacity in sea-level residents.

Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude population

The paper compares transcriptomes of iPSC-derived cardiomyocytes from Tibetan and Han Chinese populations under hypoxia, identifying pathway differences linked to high-altitude adaptation.

Neurocognitive Vulnerability to Hypoxia Across Cognitive Domains: A Systematic Review and Meta-Analysis

This study quantifies hypoxia's impact on cognitive performance across domains using 46 studies, finding significant impairments in processing speed, long-term storage, and psychomotor speed.

Transcriptomic study of testicular hypoxia adaptation in Tibetan sheep

This study identifies differentially expressed genes and pathways in Tibetan sheep testicular tissue under hypoxia, suggesting their role in reproductive adaptation to high altitude.

Hypoxia responses in arginase 2 deficient mice enhance cardiovascular health

This study shows that deleting arginase 2 in mice improves cardiovascular health under chronic hypoxia by increasing nitrite and arginine levels while reducing pulmonary hypertension.

The Effects of Living at Altitude on the Prevalence of Dementia

This study simulates mitochondrial dynamics at altitude to show reduced neuron loss and cognitive decline associated with high-altitude living.

Multi-omics Reveals Immune Response and Metabolic Profiles during High-Altitude Mountaineering

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

Downregulations of mRNA expressions in the EPAS1and EGLN1: Unraveling a genetic mechanism for high-altitude hypoxia adaptation in Sherpa highlanders

This study investigates mRNA expression levels of EPAS1 and EGLN1 in Sherpa highlanders and lowlanders, finding lower expressions in Sherpa highlanders and associations with specific SNPs that may contribute to hypoxia tolerance.

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

This study generates a time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues in sheep, identifying key genes and regulatory elements involved in hypoxia adaptation.

Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress

This study identifies Bmal1 activation as a driver of mitochondrial stress and inflammation in monocytes under hypobaric hypoxia, mediated by BHLHE40 and Fis1-mediated mitochondrial fission.

A feasibility study of smartphone sensors to assess the effect of acute high altitude (3,800 m) exposure on cognition and motor function in healthy participants

This study evaluates smartphone sensors' ability to detect cognitive and motor impairments at high altitude, finding impaired fine motor skills and gait but preserved visual memory.

Differences in pathogenetic mechanism between Tibetan and Han high-altitude polycythemia based on a whole genome-wide association study

This study identifies genetic differences in HAPC susceptibility between Tibetans and Han Chinese using GWAS, revealing distinct pathways involved in each group.

Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice

The paper examines gene expression changes in highland deer mice exposed to hypoxia at different developmental stages, identifying differentially expressed gene suites and transcriptional modules linked to respiratory traits and altitude adaptation.

Identification of Global DNA Methylation Signatures in Patients of High Altitude Induced Venous Thrombo-Embolism (HA-VTE)

The paper identifies global DNA methylation signatures in high altitude-induced venous thrombo-embolism (HA-VTE) by comparing methylation patterns across different groups.

High-altitude adaptation and incipient speciation in geladas

This study identifies genomic and karyotypic changes in geladas that may contribute to high-altitude adaptation and speciation.

Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude

The paper shows that baseline psychological traits like anxiety and neuroticism, not physiological changes, are linked to AMS symptoms at high altitude.