Axon Guidance and Neuronal Signaling

The paper identifies a cell-ECM recognition mechanism that directs ipsilateral retinal ganglion cell axons to a specific sublamina of the superior colliculus, enabling eye-specific visual pathways.

This study shows that loss of the ECM protein DIG-1 in C. elegans causes glial fragmentation, dendrite breakage, and dendrite extension defects.

The paper identifies Sdk1 as a molecular factor that guides dendritic arborization in retinal ganglion cells to enable edge detection.

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.

This study identifies JNK signaling's non-autonomous role in guiding thalamocortical axon pathfinding during forebrain development.

This paper introduces an agent-based model of retinotectal axon projection using gradient following and receptor-ligand interactions to replicate experimental results without competition.

This study identifies Sema3fb's role in modulating VEGF signaling to regulate endothelial sprouting during vascular development.

This study shows that the Slit-binding Ig1 domain of Drosophila Robo2 is essential for midline repulsion and lateral axon pathway formation, and its removal disrupts these functions.

This study shows that Fmn2b is essential for motor neuron development and function in zebrafish, with loss-of-function leading to motor deficits and impaired axon branching.

This study identifies the catp-8/P5A-ATPase as a regulator of neuronal patterning in C. elegans, showing its role in dendrite morphogenesis, axon guidance, and neuronal migration through multiple genetic pathways.

This study shows that vinculin's tail domain affects neuronal migration and axon growth through actin interactions, independent of talin.

This study shows that cleaved SAX-7S fragments, not full-length protein, maintain neuronal architecture in C. elegans after development.

This study shows that the loss of ephrin-B3 function in birds shapes spinal flight circuitry by enabling synchronous wing flapping through altered midline signaling.

The paper shows that reciprocal repulsions between Teneurin-3 and Latrophilin-2 guide the assembly of parallel hippocampal networks during development.

The paper shows that syntaxin-1 is required for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion in axonal guidance.

The paper shows that Loaf protein levels in R7 photoreceptors and their synaptic partners determine axon targeting accuracy in Drosophila.

This study shows that miRNA-22a in blood vessels guides motor neuron pathfinding in zebrafish via exosomes and regulates vascular and neuronal patterning.

This study shows that BMP signaling disrupts optic chiasm formation and retinal ganglion cell (RGC) pathfinding in zebrafish by affecting midline guidance cues and optic stalk morphogenesis.

This study quantifies proteomic changes during human neurosphere differentiation, identifying upregulated axon guidance pathways and a functional assay for neurite outgrowth.

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.

This study identifies Sema3F's role in dendritic spine pruning through Rho-GTPase signaling pathways in cortical neurons.

The paper screens 493 kinase inhibitors to identify roles of Aurora and Nuak kinases in neurite initiation and dendritic branching using Neuro2a cells and primary cortical neurons.

This study characterizes the role of Slit2 in optic axon organization in zebrafish by analyzing a null mutant and showing defects in axon sorting at the optic chiasm and proximal tract.

This study identifies the WRC as a conserved effector of Robo signaling in axon repulsion across species.

The paper identifies Lumican as a factor regulating axon collateralization in cervical corticospinal neurons through inter-neuronal crosstalk.

The paper investigates the role of Sema3C in guiding MGE-derived cortical interneurons during migration, showing that Nrp1-expressing interneurons are attracted to Sema3C gradients.

The paper shows glial insulin modulates Gogo phosphorylation, which controls R8 axon navigation in Drosophila by switching between recognition and suppression of Flamingo interactions.

This study shows that Endoglycan negatively regulates cell-cell adhesion, affecting axon guidance and neuronal migration in the central nervous system.

This study identifies DPY-17 and SQT-3 Collagens as regulators of left-right asymmetric migration of Q neuroblasts in C. elegans.