Dong Liu

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

This study identifies HSD17B7 as critical for sensory hair cell function by regulating cholesterol synthesis, showing its role in auditory physiology and hearing loss.

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

The paper identifies Cxcl12a as a signaling molecule guiding long-distance vascular migration in zebrafish pectoral fins through monocyte-derived cues.

This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

The paper profiles chromatin accessibility dynamics in zebrafish embryos using single-cell ATAC-seq to identify enhancers and transcription factor motifs involved in early cell fate decisions.

This paper tests a light-controlled phosphorylation method at the TrkA-Y785 site to study its effect on the MAPK/ERK signaling pathway.

This study presents the first high-quality chromosome-level genome assembly of Trachidermus fasciatus using nanopore, Illumina, and Hi-C sequencing.

This study shows that miRNA-22a in blood vessels guides motor neuron pathfinding in zebrafish via exosomes and regulates vascular and neuronal patterning.

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.

This study identifies molecular risk factors and mechanisms in idiopathic cerebral palsy through clinical and molecular analysis of 120 families.

This study identifies a THOC1 variant causing late-onset nonsyndromic hearing loss via p53-mediated hair cell apoptosis in zebrafish.

This study shows that MECP2 duplication and mutations impair neural stem cell differentiation through miR-197 regulation of ADAM10 and NOTCH signaling.

This study identifies Insm1a as a critical regulator of motor neuron development in zebrafish, showing it modulates olig2 and nkx6.1 expression to affect neuronal differentiation and function.