Axon Guidance and Neuronal Signaling

This study shows UNC-6/Netrin promotes both adhesion and directional growth in C. elegans axons through distinct mechanisms involving haptotaxis and chemotaxis.

The paper shows TRIM46 is not required for axon specification or AIS formation in mice, contradicting previous cultured neuron studies.

This study shows that Netrin/Dscam1 signaling dynamically regulates axonal projection direction in Drosophila s-LNv neurons through temporal changes and local microenvironment interactions.

This study identifies two distinct roles of Plexin A in Drosophila medulla development: one for neuropil morphogenesis requiring its cytoplasmic domain and another for layer formation via Semaphorin 1a.

This study identifies cadherin 4 as a key molecule for layer-specific targeting of retinal ganglion cells in sublaminae 1 and 3a, affecting their connectivity and visual responses.

The paper shows that dendritic growth is stochastic and ligand-free, while ligand binding inhibits growth and specifies shape in C. elegans neurons.

This study identifies hkb as a regulator of DIP- expression and target recognition in specific Drosophila motor neurons, revealing distinct transcriptional control mechanisms.

This study shows that KNL-1 and the NDC-80 complex are essential for proper axonal organization in C. elegans, revealing a non-canonical role for the KMN network in nervous system development.

This study identifies UNC-16's role in axon termination through interactions with LRK-1 and WDFY-3, highlighting the endolysosomal system's involvement.

This study shows Tet regulates axon guidance in Drosophila brain development via glutamatergic signaling, with Gs2 as a key mediator.

The paper identifies neurexin gene expression patterns in olfactory sensory neurons that guide axonal targeting to specific glomeruli through interactions with neuroligins in mitral/tufted cells.

The paper identifies topographic principles in the corpus callosum that guide axon connectivity between brain hemispheres through symmetric adhesion molecule levels and co-fasciculation.

This study shows that Sema3E-Plexin-D1 signaling activates Mtss1 to coordinate axonal extension and steering during neuronal pathfinding.

The paper identifies phosphorylation sites in PLPPR3 and shows that phosphorylation at S351 regulates its interaction with BASP1, suggesting a role for the PLPPR3-BASP1 complex in synaptic signaling.

This study shows that tissue stiffness regulates Eph/ephrin signalling in the Xenopus optic pathway, with mechanical gradients correlating with EphB and ephrinB expression patterns.

This study shows that EphB1 in GABAergic neurons is essential for guiding cortical glutamatergic axons during brain development by preventing them from following blood vessels.

This study designs and tests an optogenetic EphA1-Cry2 fusion to selectively activate EphA1 signaling without ligand, characterizing MAPK phosphorylation as a key signaling target.

This study identifies non-redundant roles of Plexin-B1 and Plexin-B2 in GABAergic synapse formation through structure-function analysis and presynaptic expression studies.

This study shows that netrin-1-induced axonal haptotaxis is mediated by mechanical coupling between netrin-1 and its receptor DCC, facilitated by shootin1a and actin flow.

The paper investigates how semaphorin signaling regulates cell shape in C. elegans epidermis using mosaic gene expression analysis with IR-LEGO.

This study shows that Drosophila Dpr and DIP proteins are GPI anchored, and this modification is necessary for their cell surface organization and function.

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

This study examines retinotectal projections and visuomotor behavior in one-eyed Xenopus laevis, finding impaired pathfinding and behavioral compensation.

The paper qualitatively describes individually-tagged serotonergic axons in mouse telencephalic regions using Brainbow labeling and confocal microscopy.

This study shows that Sema6A, expressed by retinal ganglion cells, is essential for delineating OFF and ON functional domains in the inner plexiform layer of the mouse retina.

The paper identifies genetic and proteomic interactions between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub in C. elegans neurons, showing their role in axon development and neurodevelopmental disorders.

This study generates a conditional knockout mouse model to investigate the physiological role of SEMA6A reverse signaling in nervous system development, revealing its importance in axon pathfinding and neuron migration.

The paper investigates axonal development in Basket cells, finding that axons from dendrites develop higher complexity than those from cell bodies, influenced by spontaneous activity.

The paper shows how ligand-directed competition between RIP2 and RhoGDI for p75NTR engagement determines axon growth and neuron survival.

This study identifies drebrin's role in regulating axon branching in cortical neurons and develops tools to analyze single-cell morphology.