Hippo pathway signaling and YAP/TAZ

This study shows that Yap proteins are essential for cell migration during embryo axis formation by regulating cytoskeletal organization and cell-ECM adhesion in medaka.

The paper shows the Hippo pathway regulates axis formation in Hydra, upstream of Wnt, by controlling budding, actin organization, and cell proliferation.

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

This study identifies YAP and TAZ as transcriptional co-activators of AP-1 and STAT3 in breast cancer, showing their role in gene regulation and poor patient survival.

This study shows YAP/TAZ are essential for maintaining radial glial cell function during brain development, affecting neuronal and ependymal cell numbers and causing hydrocephaly when disrupted.

This study identifies Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate in Drosophila eye, distinct from their role in Hippo-dependent organ growth.

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.

The paper identifies STRIPAK-dependent phosphorylation sites in SmKIN3 and shows their impact on septation in Sordaria macrospora.

This study identifies the Hippo pathway components in Hydra and shows their role in head regeneration and bud development through YAP expression patterns and functional analysis.

This study shows YAP1 is essential for proper germ layer patterning in hESCs-derived gastruloids by regulating NODAL signaling and repressing mesoendodermal differentiation.

The paper shows the Hippo pathway downregulates Kibra levels through SCFSlimb-mediated ubiquitination, independent of Yorkie, to control tissue growth.

This study identifies the Hippo pathway's role in regulating sarcomeric gene expression to control myofibril assembly and muscle fiber growth in Drosophila.

This study shows that alternative splicing of yorkie is essential for developmental stability in Drosophila by modulating Yki protein function and reducing developmental noise.

The paper shows that proliferation termination in Drosophila wing discs occurs due to reduced TORC1 activity, independent of Dpp or Hippo/Yorkie signaling.

This study shows that maternal vgll4a coordinates blastomere adhesion and cohesion during zebrafish epiboly, enabling Yap1-mediated mechano-transduction.

This study identifies Syd/JIP3 as a regulator of tissue size by controlling Diap1 protein turnover downstream of Yorkie/YAP, showing conservation between Drosophila and mammalian cells.

The paper uses network analysis to identify genetic sub-networks regulating reproductive capacity in Drosophila by integrating functional genetic data with protein-protein interactions.

This study shows YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation to accelerate bone fracture healing.

This study investigates Yap haploinsufficiency in mice, revealing its role in Müller glia dysfunction and late-onset cone dystrophy in aged individuals.

The paper identifies tumor suppressor genes interacting with EGFR and Yki in Drosophila using RNAi screens and finds novel connections to growth regulation.

The paper identifies DOCK5 as a regulator of YAP/TAZ localization and cell shape during migration, showing its role in maintaining polarity through interactions with CDC42, RAC, and RHOA.

This study shows that Twist regulates Yorkie to enable lineage reprogramming of syncytial alary muscles in Drosophila.

This study identifies thrombospondin-1 as a mediator of matrix mechanotransduction in vascular remodeling, showing its role in integrin signaling and YAP nuclear shuttling under mechanical stress.

This study identifies Pits and CtBP as Tgi-interacting proteins that cooperate in transcriptional repression of Hippo pathway target genes in Drosophila, with conservation in human orthologs.

This study identifies Hippo signaling's role in inducing apical and basal cell extrusion in Drosophila wing discs, with Ets21c mediating apical extrusion and bantam mediating basal extrusion.

The paper shows that blastomere position during early embryogenesis influences YAP localization through apicobasal polarity and PKC signaling, affecting cell fate decisions.

The paper identifies CtBP as a negative regulator of growth that antagonizes Yorkie and JNK/AP-1 pathways by restricting bantam microRNA expression.

This paper identifies Yorkie's dual role in regulating tracheal tube length and apical barrier integrity in Drosophila airways through cytoplasmic and transcriptional mechanisms.

The paper shows that Yap/Taz-TEAD activity mediates mechanical signal sensing in hindbrain boundary cells, linking mechanical cues to progenitor behavior and cell fate changes.