Pneumocystis jirovecii pneumonia detection and treatment

This paper trains a machine learning model to predict antifolate resistance mutations in Pneumocystis jirovecii using experimental data and computational modeling, finding mutations that confer resistance to trimethoprim-sulfamethoxazole.

This paper develops a method to genetically modify Pneumocystis murina using extracellular vesicles for CRISPR/Cas9 delivery, achieving stable in vivo gene editing and transgene expression.

This study uses scRNA-seq to map the life cycle of Pneumocystis carinii, identifying transcriptional states associated with developmental stages and reproductive transitions.

This study identifies NLRP3 inflammasome activation and NETosis in P. murina pneumonia, highlighting neutrophils' role in inflammation and tissue damage.

The paper shows that B cell CD40 expression is necessary for effective immunity against Pneumocystis infection in mice.

The paper characterizes the diversity and evolution of the Msg gene superfamily across Pneumocystis species, revealing its functional roles in immune evasion and host adaptation.