Psychedelics and Drug Studies

This paper analyzes 6,850 hallucinogenic experiences to link drug-induced consciousness changes to brain receptor distributions using natural language and gene expression data.

This study uses PET/fMRI in rats to show MDMA causes global hemodynamic decreases and localized metabolic increases, indicating neurovascular uncoupling due to serotonin transporter occupancy.

The paper examines how non-synonymous SNPs in the 5-HT2A receptor gene affect the potency and efficacy of four psychedelic drugs in vitro.

This study investigates whether LSD microdosing affects working memory recall and distracter resistance vs. updating, finding no significant effects.

This study investigates the effects of microdosing psilocybin mushrooms using a double-blind placebo-controlled design and finds that active doses produce more intense subjective effects, with mixed results on other measures.

This study shows that the hallucinogenic 5-HT2A agonist DOI increases CREB-dependent expression of plasticity-associated genes in the rodent neocortex.

This study examines how psychedelic drugs and intrinsic brain state transitions affect neuronal firing rate distributions in mice, revealing a common pattern of stretching and squeezing in log-rate distributions across different brain states.

The paper integrates transcriptomics with large-scale cortical modeling to simulate LSD's effects on brain function, revealing serotonin-2A receptor-mediated changes in cortical connectivity.

This study shows that psilocin levels and subjective drug intensity correlate with changes in brain network integrity and segregation after psilocybin administration.

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.

This study examines changes in resting-state functional connectivity after a single psilocybin dose in healthy individuals, finding decreased executive control network connectivity at one-week and a link to increased mindfulness at three-months.

This study examines how different stroboscopic stimulation frequencies affect neural dynamics and self-reported experiences, finding that alpha band frequencies cause the most significant changes.

This study shows that LSD increases signalling entropy in rats' prefrontal cortex by rewiring gene co-expression networks, suggesting a link between molecular changes and brain entropy.

This study investigates the neural correlates of the shamanic state of consciousness using EEG in practitioners and controls, finding distinct brain activity patterns compared to psychedelic-induced states.

The paper investigates how baseline theta oscillation power predicts mystical-type experiences induced by DMT and suggests ways to enhance these experiences.

This study examines how psilocybin dose affects subjective experiences in humans using meta-regression on standardized questionnaires.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.

This study shows psilocin disrupts sleep patterns and affects local but not global sleep homeostasis in mice, potentially linking to its antidepressant effects.

This study investigates how LSD affects behavior in mice lacking beta-arrestin 1 or 2, revealing distinct roles for these proteins in mediating LSD's effects.

This paper uses a whole-brain computational model to simulate perturbations under LSD and finds increased dynamical complexity and recovery time, with strongest effects in resting state networks.

This study investigates the electrophysiological effects of ibogaine in rats, finding increased gamma oscillation power with reduced coherence and complexity, suggesting REM sleep traits in the psychedelic state.

This study investigates how sub-anaesthetic ketamine affects EEG signal diversity and finds increased spontaneous signal diversity correlates with altered consciousness.

This paper develops a mechanistic model explaining how 5HT2A-R activation increases neural entropy in the brain, showing non-uniform regional effects linked to anatomical connectivity.

This study examines how psilocybin affects functional connectivity in mice, revealing distinct changes in serotonin and dopamine-related networks.

This study investigates how DMT alters cortical travelling waves during a resting state, finding reduced backward and increased forward waves, supporting a model of altered precision-weighting of priors.

This study shows psilocybin improves social behavior in a prenatal valproic acid-induced ASD mouse model.

This study examines the neural and subjective effects of inhaled DMT in natural settings using EEG and psychometric questionnaires, finding changes in brain oscillations and correlations with mystical experiences.

This paper shows that LSD and psilocybin increase the fractal dimension of brain activity in both spatial and temporal domains, suggesting a shift toward criticality in neural systems.

This study examines changes in directed functional connectivity during the psychedelic state using MEG and finds a general decrease in directed connectivity for LSD, psilocybin, and low-dose ketamine.

This study identifies distinct neural mechanisms for MDMA's prosocial effects and rewarding properties in mice, showing serotonin transporter and dopaminergic signaling play separate roles.