FOXO transcription factor regulation

This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.

The paper identifies three muscle-specific DAF-16/FOXO targets activated by reduced insulin/IGF-1 signaling in C. elegans through transcriptomic and chromatin analyses.

This study identifies FoxO1-dependent autophagy as a conserved mechanism for regression of physiological cardiac hypertrophy across species.

This study shows that daf-16/FOXO promotes multipotency in C. elegans dauer larvae by upregulating lin-41/TRIM71, which blocks premature adult cell fate markers.

This paper investigates the transcriptional regulation of lipid and glucose metabolic genes in hepatic insulin resistance, finding distinct regulatory patterns and a model for their coexistence in type 2 diabetes.

The paper identifies a FOXO-dependent mechanism that restricts proliferation of cells with mild replication stress by promoting premature activation of APC/CCDH1.

This study shows that disrupting mitochondrial electron transport chain (ETC) in Drosophila intestinal stem cells (ISCs) impairs their differentiation, likely through increased FOXO signaling.

This study investigates age-related changes in FOXO transcription factor gene targeting in Drosophila melanogaster using ChIP-Seq, revealing a decline in FOXO-bound genes and shifts in targeted biological processes with age.

This study identifies a physical and genetic interaction between dFOXO and Kr-h1 in Drosophila, showing that Kr-h1 represses lipolysis by regulating adipose lipase brummer transcription.