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Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

This paper demonstrates sonogenetic cardiac pacing using hsTRPA1-expressing cardiomyocytes, showing ultrasound can noninvasively modulate heart rate in mice.

This paper introduces vascularized tumor organoids (VascO) to model tumor microenvironments for immunotherapy testing, showing they can assess drug safety and efficacy in a patient-specific context.

This study characterizes epithelial cell states emerging from reprogramming in a pulmonary bioengineering context.

Entomoscope 2.0 and ENIMAS 2.0 provide an open-source, AI-integrated platform for rapid, affordable insect digitization, achieving faster processing than commercial systems.

This study shows that glycation of dentinal collagen with methylglyoxal improves its resistance to enzymatic degradation and enhances resin-dentin bond strength.

This paper introduces NAFNet GAN, a bioimage restoration framework that achieves high fidelity and low latency, suitable for real-time microscopy applications.

This study investigates how the extracellular matrix affects AAV gene therapy by comparing diffusion and transduction efficiency across different AAV serotypes and ECM models.

This paper evaluates a konjac glucomannan-montmorillonite hybrid in mice, showing reduced weight gain and improved metabolic markers.

The paper introduces BLOC, a modular organ-on-a-chip system that allows flexible configuration for diverse applications in MPS research.

This study improves cellulase activity through protein supercharging, identifying a variant with 2-3-fold higher activity on cellulosic substrates and demonstrating its synergistic potential with endocellulases.

The paper develops a modularized stretchable microneedle array for efficient drug delivery, showing improved penetration rates and reduced residual strain in porcine skin.

This study develops lung-targeted IL-10 mRNA lipid nanoparticles that reduce acute lung injury in a mouse model by attenuating inflammation and tissue damage.

The paper develops and validates new methods for ECM decellularization and collagen purification that preserve structural and biochemical integrity, applicable to various cell types for tissue engineering and drug discovery.

This study develops a WSAO-OCT platform to visualize retinal cells in live mice, showing improved image quality and detecting RGC degeneration after optic nerve injury.

This paper introduces AddGraft, a biocompatible additive enabling spatiotemporal modification of hydrogel properties for 3D tissue engineering.

Regularized single-cell imaging in nanowells enables training of generalizable AI models for accurate, stain-free viability screening across previously unseen cell types and contexts.

The paper develops a multi-parametric imaging system to study cAMP, transmembrane potential, and calcium in the heart, showing cAMP activation correlates with electrophysiological responses.

The paper introduces 3D spheroid-based skin models and a deep-learning pipeline to study keratinocyte differentiation and barrier function, identifying NHK-E6/E7 as the best alternative to primary keratinocytes.