Discover, rate, and discuss biology preprints.

This paper develops a computational model to simulate HIV-1 capsid rupture during reverse transcription and shows how capsid-DNA interactions drive distinct rupture pathways.

The paper uses quantum walk analysis to show that a conserved structural bottleneck in mitochondrial complex I redistributes electron flux through alternative pathways across species.

The paper introduces a robotic system for cryo-EM grid preparation that improves sample efficiency and reconstruction quality.

This study compares AI tools for predicting protein structural ensembles, finding they generate diverse but distinct conformational distributions, with limited coverage of experimental structures and minimal response to known mutations.

The paper develops a deformation gradient tensor model to describe the roll-spiral transformation in protein refractile bodies, linking macroscopic morphology with microscopic lattice deformation.

This study creates age and gender-stratified group-average brain models to analyze biomechanical responses to traumatic brain injury, finding significant demographic differences in deformation patterns.

This paper uses Bayesian optimisation and graph-based rheology to model DNA materials by linking sequence design to material properties.

This study investigates whether genomic language models have learned RNA thermodynamics by analyzing their pairwise dependencies using the categorical Jacobian operation and comparing them to biophysical models.

This paper introduces Rheo-FLUCS, a probe-free method to measure cell mechanics using light-induced flows, showing equivalence to active microrheology in different biological systems.

This paper maps hyperthermal sarcomeric oscillations to a quantum hardware model and demonstrates repeatable execution of biologically meaningful observables, showing constrained local reconfiguration rather than maximal mixing.

This study identifies β-furanoside-5'-phosphate as the preferred RNA scaffold through biophysical selection, showing its enhanced lipid permeability and enrichment in protocells.

This paper introduces a single-particle microscopy method to directly count mRNA copies in lipid nanoparticles, showing differences in mRNA copy number, size, and empty fraction between two formulations.

This paper shows how introducing reversible dimerization into a Flory-Huggins model creates an effective three-body repulsion, explaining reentrant phase transitions in biomolecular condensates.

The paper uses SMART-epi to study how m6A modification affects RNP granule assembly and RNA interactions, revealing functional divergence among YTHDF proteins.

DeepDiffusion detects heterogeneous diffusion in single-molecule trajectories using a physics-informed neural network, accurately identifying subtle changes despite large errors.

This paper demonstrates that flavoproteins like cryptochrome and iLOV exhibit optically detected magnetic resonance, enabling magnetic field sensing and photoluminescence modulation via radiofrequency pulses.

This study shows that phosphorylated serine clusters in HP1 can sense metal ions, altering phase separation behavior through metal coordination.

The paper demonstrates that bacterial flagellar torque has two components driving spin and precession, supported by bead assay experiments and a mechanical model.

The paper introduces an efficient method for detecting double helix structures in 3D single-molecule microscopy using steerable filters, achieving state-of-the-art performance with minimal user input.

This study uses MD simulations to show that preorganized thumb-subdomain motions in SARS-CoV-2 polymerase drive functional transitions through structurally coupled regulatory regions.