Rob M. Scrutton

This study examines how protein language models handle intrinsically disordered proteins, finding they encode structural and functional information despite reduced attention on disordered regions.

This study introduces ExVivo PhaseScan to generate high-resolution phase diagrams of physiological protein condensates and reveals how FUS mutations cause liquid-to-solid transitions in stress granules and nucleoli.

This paper shows how introducing reversible dimerization into a Flory-Huggins model creates an effective three-body repulsion, explaining reentrant phase transitions in biomolecular condensates.

This study uses lipidation to control biomolecular condensate properties and interactions, enabling the creation of multi-phase hydrogels that guide intestinal organoid morphogenesis.

The paper quantifies how different excipients affect the solubility of therapeutic antibodies using a high-throughput platform and identifies molecular-specific and nonspecific interactions.

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

This paper introduces a framework for quantitatively analyzing phase diagrams of multicomponent systems, revealing two scaling regimes for phase boundaries.

This paper investigates the molecular mechanisms of opalescence and liquid-liquid phase separation in mAb formulations and shows they are decoupled from aggregation.

This paper introduces a model-agnostic framework to condition Boltzmann generators for sampling cyclic peptide conformations without retraining, using chemically informed loss functions and geometric constraints.

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.

The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.

The paper investigates how temperature affects G3BP1-RNA phase separation, revealing that while the phase boundary remains stable, stoichiometry and energetics shift, driven by entropic processes.