Daoyuan Qian

This study shows that complex coacervation changes tau aggregation by redirecting it to a distinct kinetic regime and altering amyloid properties.

This paper shows how introducing reversible dimerization into a Flory-Huggins model creates an effective three-body repulsion, explaining reentrant phase transitions in biomolecular condensates.

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

This paper introduces a framework for quantitatively analyzing phase diagrams of multicomponent systems, revealing two scaling regimes for phase boundaries.

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

The paper investigates how temperature affects G3BP1-RNA phase separation, revealing that while the phase boundary remains stable, stoichiometry and energetics shift, driven by entropic processes.