Discover, rate, and discuss biology preprints.

This study investigates how PD-L1 deletion or blockade affects macrophage antigen presentation and checkpoint molecule levels in different polarization states.

This study shows that immunological imprinting in mice uncouples serological and B-cell responses, with B-cell repertoires updating independently of serum antibody specificity.

This study identifies Gpr149 as an endogenous antigen in SB28 glioblastoma that can be targeted by vaccination to induce protective immunity against checkpoint inhibitor-refractory tumors.

This paper uses AlphaFold 3 to predict T cell receptor antigen specificity from sequence, achieving high accuracy on unseen epitopes.

This paper uses mathematical models to investigate T cell differentiation pathways during ex vivo expansion, finding that differentiation is dynamic and not unidirectional, with implications for improving adoptive T cell therapy.

This study shows that vaccinating pregnant mares with mRNA encoding GPI-anchored VapA of R. equi leads to transfer of VapA-specific IgG to foals, providing passive immunity.

The paper designs a synthetic consensus IFN-β for bats that induces IFN-I signaling across diverse bat species, enabling study of antiviral immunity.

This study shows that ESX-5 deletions in Mtb reduce cytokine secretion in macrophages via a post-transcriptional mechanism and alter heavy metal response genes.

This study uses scRNA-seq to analyze the immune response to CHIKV infection, finding increased monocytes and dendritic cells, and a strong interferon response driven by monocytes.

This study examines immune cell changes in obesity and after bariatric surgery, finding preserved type 2 immune cell plasticity and differential immune recovery.

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

The paper assesses whether HIV-1 infection confers resistance to CTL-mediated cell death and finds no intrinsic resistance, with survival differences attributed to MHC class I downregulation.

This study identifies a microbial-immune-epithelial feedback mechanism that regulates stem cell activity and skin barrier function through prostaglandin E2 signaling.

This study identifies versikine, a matrikine derived from VCAN proteolysis, as essential for organizing dendritic cell-T cell triads in tertiary lymphoid structures and enhancing antitumor immunity.

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

This paper develops a vaccine platform using MS2 viral capsids to deliver an Mtb antigen and STING agonist, reducing the required dose and cost while maintaining efficacy.

This study isolates and characterizes monoclonal antibodies against Toscana virus's Gc glycoprotein, identifying cross-reactive antibodies that protect against Rift Valley Fever Virus.