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This study uses a zebrafish model to show mycobacteria cause transient vascular occlusions and ischemia during early brain infection, establishing a model for TBM vascular complications.

This paper introduces VQ-MIL, a weakly supervised vector quantization method for WSI classification, achieving state-of-the-art results on benchmark datasets.

This study shows melatonin alleviates lysosomal damage in diabetic kidney disease by upregulating TFEB and the miR-205-5p-LRP-1 pathway, improving autophagy and oxidative stress.

This paper investigates the link between low choline levels, obesity, metabolic dysfunction, and neuropathology in humans and 3xTg-AD mice, finding sex-specific and obesity-related associations.

This study uses spatial transcriptomics to compare gene expression in intima and media of human coronary arteries, revealing dedifferentiated SMCs in DIT that differ from proinflammatory SMCs in atherosclerotic lesions.

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.

This study shows SCFAs promote angiogenesis in PAD by activating FFAR3, while Palmitate impairs it, and FFAR3 loss blocks SCFA benefits.

This study describes the cardiac phenotype of DE50-MD dogs, a dystrophin-deficient model of DMD, showing early cardiac changes similar to human DMD patients.

This paper introduces a protocol for 3D multiplexed immunohistochemistry using Opal-TSA conjugated fluorescent dyes to enhance imaging of pulmonary TB lesions in mouse tissues.

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

This study uses a Complex Adaptive Systems framework to analyze health outcomes of 19th-century migrants to South Australia by integrating bioarchaeological and historical data.

This paper develops a RPA-DETECTR assay for rapid, sensitive, and specific detection of Foc TR4, outperforming PCR and qPCR in speed and sensitivity.

This study identifies key functional regions of GGCX and their interactions with FIX using AlphaFold 3 and simulations, revealing residues critical for carboxylation and vitamin K epoxidation.

This study shows that pathological tau isoforms in retinal ganglion cells (RGCs) are linked to RGC degeneration in Alzheimer's disease, with significant correlations between tau levels and disease severity.

This study characterizes SVNV proteins through sequence analysis of field strains and compares their localization in plant and insect cells.

This study shows that higher parasite burden in vertebrate hosts leads to shorter extrinsic incubation periods in mosquitoes, but not increased transmissible stages.

This study shows that a diet enriched with deuterium-reinforced polyunsaturated fatty acids (D-PUFA) prevents muscle atrophy and weakness in STZ-induced diabetic mice.

The paper reports that male mice undergoing general anesthesia with fentanyl, midazolam, and medetomidine develop obstructive uropathy, while using xylazine instead prevents this complication.

This study re-establishes the golden Syrian hamster as an MCF model and identifies T cells and macrophages as key infected cells, with broader viral tropism including endothelial cells and epithelia.