Jonathan W. Nelson

This paper introduces an annotation-based gene-peak linkage method that improves gene expression prediction from chromatin accessibility in human kidney multi-omics data.

The paper identifies three distinct cell types in thick ascending limb cells across species, each with unique potassium channel and claudin expression patterns that influence cation transport.

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

This study shows that remyelination protects neurons from DLK-mediated neurodegeneration by preventing apoptosis and inflammation in a mouse model of demyelination.

The paper uses snRNA-seq to analyze DCT cells, revealing distinct functional subtypes DCT1 and DCT2 with different gene expression patterns and developmental origins.

The paper examines GPR39 localization in aged human brains and correlates its expression and polymorphism with vascular cognitive impairment.