Discover, rate, and discuss biology preprints.

This study examines the 24-hour excretion patterns of urinary extracellular vesicles (uEVs) and their cargo in healthy subjects, revealing temporal variations and associations with urine parameters.

Sodium tungstate enhances vascularization and improves survival of transplanted insulin-producing cells in diabetes models by upregulating VEGFA and promoting endothelial cell function.

This study reviews heat exposure's impact on pregnancy outcomes across species, finding increased risks of preterm birth and low birthweight, particularly in the third trimester.

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

This study quantifies age-related differences in lower limb muscle volume across 17 muscles in young and older adults, revealing significant heterogeneity in atrophy patterns.

The paper develops a mathematical model to study how estrogen decline and RAS inhibitors affect bone remodeling and calcium homeostasis in post-menopausal women.

The paper uses non-linear growth models combined with survival rates to determine the optimal rearing temperature and harvest timing for two cricket species.

The paper identifies that air bubbles in water bottles can cause dehydration in mice, and proposes a coiled wire solution to prevent this.

This paper evaluates dive profile metrics under the Buhlmann decompression algorithm to quantify deviations in open water dives and identifies the best-performing metric.

This study identifies the m6A-SIRP axis as a regulator of efferocytosis in atherosclerosis, showing myeloid m6A loss increases plaque instability.

This study evaluates whether renal arterial hemodynamic measures reflect renal sympathetic innervation in preclinical models, finding inconsistent results.

This paper introduces a rapid, reproducible soil-based protocol for screening drought tolerance in small grain cereals and their wild relatives at the seedling stage, showing consistent results across developmental stages.

This study identifies MATR3's role in oocyte growth and maturation through transcriptional regulation and paracrine signaling, showing its importance in fertility and potential as a therapeutic target for OMA.

This study investigates the inotropic effects of 3-hydroxybutyrate in rat hearts using pressure-volume analysis and isolated ventricular trabeculae, finding direct myocardial improvement independent of beta-adrenergic signaling.

This study examines how daily physical activity behavior changes during a 12-week power training intervention in older men and its associations with physical adaptations.

This study examines how acute caffeine affects motor unit behavior during submaximal and fatiguing contractions, finding changes in discharge rate and variability without enhancing maximal force or fatigue resistance.

This study investigates how food restriction in a mouse model of anorexia nervosa affects gut microbiota and intestinal gluconeogenesis, revealing their roles in maintaining glucose homeostasis.

This study shows Gβγ enhances M-current by increasing channel surface expression and stabilizing PIP2 coupling in Xenopus laevis oocytes.

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.